NTS (Neurotensin) Gene
A comprehensive resource for the NTS gene, including genomic data, expression, mutations, and associated diseases.
Gene Information Card
| Symbol | NTS |
|---|---|
| Full Name | Neurotensin |
| Gene Type | protein-coding |
| Chromosomal Location | 12q21.31 |
| NCBI Gene ID | 4922 ncbi.nlm.nih.gov/gene/4922 |
| Ensembl ID | ENSG00000133636 |
| UniProt ID | P30990 |
| OMIM ID | 162650 |
| HGNC ID | 8038 |
| Aliases | NT, NTS1, NN |
Description
The NTS gene encodes neurotensin, a 13-amino acid neuropeptide that functions as a neurotransmitter and neuromodulator in the central nervous system and as a hormone in the periphery. It is involved in dopamine signaling, pain modulation, and gut motility. NTS is also implicated in cancer, where it can promote cell proliferation and migration.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | NTS overexpression activates MAPK and PI3K/Akt pathways, promoting tumor growth and metastasis. | PMID: 23454750 |
| Breast Cancer | NTS signaling through NTSR1 enhances cell proliferation and invasion in estrogen receptor-positive breast cancer. | PMID: 21575863 |
| Schizophrenia | Altered NTS levels in cerebrospinal fluid and brain regions are associated with dopamine dysregulation. | PMID: 10446204 |
| Irritable Bowel Syndrome | NTS modulates intestinal motility and secretion, contributing to symptoms. | PMID: 11083470 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.3 | Medium |
| Small Intestine | 8.7 | Medium |
| Colon | 6.5 | Low |
| Stomach | 5.2 | Low |
| Pancreas | 3.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y | 15.4 | Neuroblastoma cell line; high NTS expression |
| HT-29 | 9.8 | Colorectal adenocarcinoma; moderate expression |
| MCF-7 | 7.2 | Breast cancer; moderate expression |
| HeLa | 2.1 | Cervical cancer; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.79G>A (p.Glu27Lys) | Missense | <0.01% | Unknown; rare variant in population databases |
| c.214C>T (p.Arg72Trp) | Missense | <0.01% | Unknown; rare variant in population databases |
| c.315_316insA | Frameshift | <0.01% | Predicted loss of function; not observed in ClinVar |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.315_316insA) are predicted to cause loss of function due to premature truncation.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in NTS.
Dominant Negative (DN)
No evidence for dominant-negative effects in NTS.
View complete mutation data：
Gene Ontology (GO)
| • neuropeptide hormone activity (GO:0005184) | • extracellular region (GO:0005576) |
| • neuropeptide signaling pathway (GO:0007218) | • insulin secretion (GO:0030073) |
| • response to drug (GO:0042493) |
Pathways
• Neurotensin signaling pathway (Reactome: R-HSA-416476)
• GPCR downstream signaling (Reactome: R-HSA-388396)
Protein Summary
Neurotensin is a 13-amino acid peptide (sequence: pELYENKPRRPYIL) derived from a 170-amino acid precursor. It binds to three receptors: NTSR1, NTSR2, and NTSR3 (sortilin). The peptide modulates dopamine transmission, pain perception, and gut function. In cancer, NTS acts as a growth factor via NTSR1, activating MAPK and PI3K pathways.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NTSR1 Knockout HEK293 Cell Line | EDJ-KQ1594 | Human | 4923 | Details Get a Quote |
| NTS Knockout HEK293 Cell Line | EDJ-KQ2476 | Human | 4922 | Details Get a Quote |
| NTSR2 Knockout HEK293 Cell Line | EDJ-KQ7426 | Human | 23620 | Details Get a Quote |
| NTS Knockout A-549 Cell Line | EDJ-KQ23044 | Human | 4922 | Details Get a Quote |
| NTSR1 Knockout HCT 116 Cell Line | EDJ-KQ21278 | Human | 4923 | Details Get a Quote |
| NTS Knockout HeLa Cell Line | EDJ-KQ21689 | Human | 4922 | Details Get a Quote |
| NTSR1 Knockout HeLa Cell Line | EDJ-KQ54034 | Human | 4923 | Details Get a Quote |
| NTSR2 Knockout HeLa Cell Line | EDJ-KQ55784 | Human | 23620 | Details Get a Quote |
| NTSR1 Knockout A-549 Cell Line | EDC90450 | Human | 4923 | Details Get a Quote |
| NTSR2 Knockout A-549 Cell Line | EDJ-KQ64279 | Human | 23620 | Details Get a Quote |
| NTS Knockout HCT 116 Cell Line | EDJ-KQ70993 | Human | 4922 | Details Get a Quote |
| NTSR2 Knockout HCT 116 Cell Line | EDJ-KQ72725 | Human | 23620 | Details Get a Quote |
