NRROS (Negative Regulator of Reactive Oxygen Species)
A gene encoding a leucine-rich repeat protein that negatively regulates NADPH oxidase activity and reactive oxygen species production, with roles in innate immunity and neuroinflammation.
Gene Information Card
| Symbol | NRROS |
|---|---|
| Full Name | Negative Regulator of Reactive Oxygen Species |
| Gene Type | Protein coding |
| Chromosomal Location | 3q29 |
| NCBI Gene ID | 375387 ncbi.nlm.nih.gov/gene/375387 |
| Ensembl ID | ENSG00000188313 |
| UniProt ID | Q86YC2 |
| OMIM ID | 615322 |
| HGNC ID | 33728 |
| Aliases | FLJ45252, LRRC33, MGC45871 |
Description
NRROS (Negative Regulator of Reactive Oxygen Species) encodes a leucine-rich repeat-containing protein that functions as a negative regulator of NADPH oxidase activity, thereby controlling the production of reactive oxygen species (ROS). The protein is involved in innate immune responses and has been implicated in neuroinflammatory processes. NRROS is also known as LRRC33.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Neuroinflammation | NRROS deficiency leads to increased ROS production and microglial activation, contributing to neuroinflammatory pathology. | PMID: 28192422 |
| Innate immune dysregulation | Loss of NRROS function results in enhanced NADPH oxidase activity and excessive ROS, impairing immune homeostasis. | PMID: 28192422 |
| Cancer (potential) | Altered NRROS expression may influence tumor microenvironment through ROS modulation; limited evidence. | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 2.1 | Low |
| Lung | 1.5 | Low |
| Spleen | 1.2 | Low |
| Liver | 0.8 | Not detected |
| Kidney | 0.6 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.5 | Low expression |
| SH-SY5Y | 1.8 | Moderate expression |
| THP-1 | 2.3 | Moderate expression |
| U87MG | 1.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34*) | Nonsense | <0.01% | Loss of function |
| c.200G>A (p.Arg67His) | Missense | <0.01% | Unknown |
| c.350_351del (p.Leu117fs) | Frameshift | <0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations in NRROS lead to truncated or absent protein, resulting in loss of negative regulation of NADPH oxidase and increased ROS production.
Gain of Function (GOF)
No gain-of-function mutations have been reported for NRROS.
Dominant Negative (DN)
No dominant-negative mutations have been described for NRROS.
View complete mutation data：
Gene Ontology (GO)
Pathways
• NADPH oxidase complex regulation
• Reactive oxygen species metabolism
• Innate immune system
Protein Summary
The NRROS protein (UniProt Q86YC2) is a 662-amino acid leucine-rich repeat-containing protein localized to the cytoplasm. It negatively regulates NADPH oxidase activity, thereby controlling the production of reactive oxygen species. NRROS is expressed in brain and immune cells and plays a role in neuroinflammation and innate immunity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NRROS Knockout HEK293 Cell Line | EDJ-KQ14500 | Human | 375387 | Details Get a Quote |
| NRROS Knockout HeLa Cell Line | EDJ-KQ59924 | Human | 375387 | Details Get a Quote |
| NRROS Knockout A-549 Cell Line | EDJ-KQ68386 | Human | 375387 | Details Get a Quote |
| NRROS Knockout HCT 116 Cell Line | EDJ-KQ76765 | Human | 375387 | Details Get a Quote |
