NRIP1 Gene - Nuclear Receptor Interacting Protein 1 | Function, Mutations & Disease

NRIP1 (nuclear receptor interacting protein 1), also known as RIP140, is a transcriptional coregulator that modulates the activity of nuclear receptors such as estrogen receptor (ER), androgen receptor (AR), and peroxisome proliferator-activated receptors (PPARs). It functions primarily as a repressor of nuclear receptor-mediated transcription by recruiting histone deacetylases and other chromatin-modifying complexes. NRIP1 plays critical roles in energy metabolism, adipogenesis, reproduction, and cancer progression. The gene is located on chromosome 21q11.2 and encodes a 1158-amino acid protein.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• Nuclear receptor signaling (R-HSA-383280)

• PPAR signaling pathway (KEGG hsa03320)

• Estrogen signaling pathway (KEGG hsa04915)

• Adipogenesis (R-HSA-381340)

NRIP1 (RIP140) is a 1158-amino acid nuclear protein that acts as a ligand-dependent coregulator for multiple nuclear receptors. It contains an N-terminal repression domain, a central nuclear receptor interaction domain with LXXLL motifs, and a C-terminal repression domain. NRIP1 recruits histone deacetylases (HDACs) and C-terminal binding protein (CtBP) to repress transcription, but can also activate transcription in certain cellular contexts. The protein is highly expressed in metabolic tissues (adipose, muscle) and hormone-responsive cancers. Post-translational modifications include phosphorylation and acetylation, which modulate its activity and stability.