NRBP2 (Nuclear Receptor Binding Protein 2)
A pseudokinase involved in cellular signaling and potential tumor suppression
Gene Information Card
| Symbol | NRBP2 |
|---|---|
| Full Name | Nuclear Receptor Binding Protein 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 8q24.3 |
| NCBI Gene ID | 340371 ncbi.nlm.nih.gov/gene/340371 |
| Ensembl ID | ENSG00000168038 |
| UniProt ID | Q9H0P0 |
| OMIM ID | 618607 |
| HGNC ID | 17869 |
| Aliases | TR2, DKFZp434B1231 |
Description
NRBP2 (Nuclear Receptor Binding Protein 2) is a protein-coding gene located on chromosome 8q24.3. It encodes a pseudokinase that belongs to the nuclear receptor binding protein family. NRBP2 is involved in cellular signaling, potentially acting as a scaffold or regulator of kinase pathways. It is expressed in various tissues and has been implicated in cancer biology, though its exact functions are still under investigation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Potential tumor suppressor; altered expression in multiple cancer types | NCBI Gene, COSMIC |
| Breast cancer | Downregulated expression; possible role in cell proliferation | COSMIC, NCBI Gene |
| Colorectal cancer | Mutations and expression changes observed | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 8.2 | Medium |
| Kidney | 6.5 | Medium |
| Liver | 5.1 | Medium |
| Brain | 3.8 | Low |
| Heart | 2.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 7.1 | Embryonic kidney |
| HeLa | 5.4 | Cervical cancer |
| MCF7 | 4.2 | Breast cancer |
| HepG2 | 3.9 | Liver cancer |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | <0.1% | Unknown |
| c.457G>A (p.Val153Ile) | Missense | <0.1% | Unknown |
| c.784A>G (p.Ile262Val) | Missense | <0.1% | Unknown |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; some mutations may reduce protein stability or interaction.
Gain of Function (GOF)
No evidence for gain-of-function mutations.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • cytoplasm (GO:0005737) |
| • nucleus (GO:0005634) | • protein kinase binding (GO:0019901) |
Pathways
• PI3K-Akt signaling pathway (potential)
• MAPK signaling pathway (potential)
Protein Summary
NRBP2 encodes a 463-amino acid protein with a pseudokinase domain, lacking catalytic activity. It contains a nuclear receptor binding motif and is localized in both cytoplasm and nucleus. The protein may act as a scaffold, modulating signal transduction pathways such as PI3K/Akt and MAPK. Its expression is regulated in development and disease, with reduced levels observed in several cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NRBP2 Knockout HEK293 Cell Line | EDJ-KQ14496 | Human | 340371 | Details Get a Quote |
| NRBP2 Knockout A-549 Cell Line | EDJ-KQ44760 | Human | 340371 | Details Get a Quote |
| NRBP2 Knockout HCT 116 Cell Line | EDJ-KQ44761 | Human | 340371 | Details Get a Quote |
| NRBP2 Knockout HeLa Cell Line | EDJ-KQ44762 | Human | 340371 | Details Get a Quote |
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