NPY1R Gene - Neuropeptide Y Receptor Y1
Complete genetic and functional information for NPY1R
Gene Information Card
| Symbol | NPY1R |
|---|---|
| Full Name | neuropeptide Y receptor Y1 |
| Gene Type | gene with protein product |
| Chromosomal Location | 4q32.2 |
| NCBI Gene ID | 4886 ncbi.nlm.nih.gov/gene/4886 |
| Ensembl ID | ENSG00000164128 |
| UniProt ID | P25929 |
| OMIM ID | 162641 |
| HGNC ID | HGNC:7956 |
| Aliases | NPYR |
Description
NPY1R encodes the neuropeptide Y receptor Y1, a G protein-coupled receptor for neuropeptide Y (NPY), peptide YY (PYY), and pancreatic polypeptide (PP). It is involved in regulation of food intake, energy homeostasis, anxiety, and vasoconstriction. The receptor is expressed in various tissues including brain, adipose tissue, and vasculature, and has been implicated in obesity, cardiovascular diseases, and certain cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Obesity | NPY1R signaling in hypothalamus regulates appetite; altered expression or function may contribute to obesity. | PMID: 10673429 |
| Anxiety | NPY1R activation in amygdala produces anxiolytic effects; dysregulation linked to anxiety disorders. | PMID: 15159515 |
| Cardiovascular diseases | NPY1R mediates vasoconstriction and cardiac hypertrophy; implicated in hypertension and heart failure. | PMID: 12135968 |
| Cancer | NPY1R expression in various tumors (e.g., breast, prostate) may promote proliferation and metastasis. | PMID: 22198343 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 8.2 | Medium |
| Adipose tissue | 5.1 | Low |
| Heart | 3.4 | Low |
| Vasculature | 6.7 | Medium |
| Gastrointestinal tract | 4.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y | 12.3 | Neuroblastoma cell line; high expression |
| MCF-7 | 7.8 | Breast cancer cell line; moderate expression |
| HepG2 | 2.1 | Hepatocellular carcinoma; low expression |
| A549 | 1.5 | Lung carcinoma; very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs1042044 | SNP | 0.32 | Missense variant (Leu7Ile) in signal peptide; associated with altered receptor expression and obesity risk. |
| rs7687423 | SNP | 0.15 | Intronic variant; may affect splicing and expression. |
| c.1058C>T | SNV | 0.01 | Nonsense variant (p.Arg353Ter); predicted to cause loss of function. |
| c.112G>A | SNV | 0.02 | Missense variant (p.Ala38Thr); affects ligand binding. |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations leading to truncated or absent receptor protein.
Gain of Function (GOF)
Missense mutations that increase receptor activity or constitutive signaling.
Dominant Negative (DN)
Mutations that produce a receptor that interferes with wild-type function, e.g., by forming inactive dimers.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • neuropeptide Y receptor activity |
| • peptide YY receptor activity | • pancreatic polypeptide receptor activity |
| • plasma membrane | • integral component of plasma membrane |
| • signal transduction | • G protein-coupled receptor signaling pathway |
| • feeding behavior | • vasoconstriction |
Pathways
• Neuropeptide Y signaling pathway
• GPCR downstream signaling
• Regulation of appetite
• Cardiac hypertrophy signaling
Protein Summary
NPY1R is a 384-amino acid G protein-coupled receptor with seven transmembrane domains. It couples to Gi/Go proteins, inhibiting adenylate cyclase and modulating intracellular calcium. The receptor is involved in diverse physiological processes including appetite regulation, anxiety, and blood pressure control. It is a potential therapeutic target for obesity, anxiety, and cardiovascular disorders.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NPY1R Knockout HEK293 Cell Line | EDJ-KQ1789 | Human | 4886 | Details Get a Quote |
| NPY1R Knockout HeLa Cell Line | EDJ-KQ54019 | Human | 4886 | Details Get a Quote |
| NPY1R Knockout A-549 Cell Line | EDJ-KQ62509 | Human | 4886 | Details Get a Quote |
| NPY1R Knockout HCT 116 Cell Line | EDJ-KQ70980 | Human | 4886 | Details Get a Quote |
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