NMUR2: Neuromedin U Receptor 2
A G protein-coupled receptor involved in energy homeostasis, stress response, and nociception.
Gene Information Card
| Symbol | NMUR2 |
|---|---|
| Full Name | Neuromedin U Receptor 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 5q33.1 |
| NCBI Gene ID | 56923 ncbi.nlm.nih.gov/gene/56923 |
| Ensembl ID | ENSG00000113594 |
| UniProt ID | Q9GZQ4 |
| OMIM ID | 605108 |
| HGNC ID | 7859 |
| Aliases | FM-3, GPR66, NMU2R, NMUR2 |
Description
NMUR2 encodes a G protein-coupled receptor for neuromedin U (NMU), a neuropeptide involved in smooth muscle contraction, feeding behavior, energy homeostasis, stress response, and pain modulation. The receptor is primarily expressed in the central nervous system and peripheral tissues, and signals through Gq/11 and Gi/o pathways.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Obesity | NMUR2 mediates NMU-induced anorexigenic effects; loss of function may contribute to hyperphagia and weight gain. | Animal models (NMUR2 knockout mice show increased food intake and adiposity); human genetic association studies (PMID: 16959961) |
| Stress-related disorders | NMUR2 activation modulates the hypothalamic-pituitary-adrenal (HPA) axis; dysregulation linked to anxiety and depression. | Preclinical studies (NMU administration alters corticosterone levels); expression changes in stress paradigms. |
| Pain (nociception) | NMUR2 expressed in dorsal root ganglia and spinal cord; NMU signaling modulates pain transmission. | Animal studies (intrathecal NMU induces hyperalgesia); receptor localization data. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain (cerebellum) | 2.1 | Low |
| Brain (hippocampus) | 1.8 | Low |
| Spinal cord | 3.5 | Medium |
| Testis | 0.9 | Not detected |
| Adipose tissue | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 1.2 | Low expression |
| HEK293 (embryonic kidney) | 0.3 | Not detected |
| U-87 MG (glioblastoma) | 0.8 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.337C>T (p.Arg113Cys) | Missense | <0.01% | Unknown; predicted to affect ligand binding |
| c.682G>A (p.Val228Ile) | Missense | <0.01% | Unknown; located in transmembrane domain |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • neuromedin U receptor activity |
| • Gq/11-coupled receptor activity | • Gi/o-coupled receptor activity |
| • plasma membrane | • integral component of plasma membrane |
| • feeding behavior | • energy homeostasis |
| • smooth muscle contraction | • positive regulation of cytosolic calcium ion concentration |
Pathways
• Neuromedin U signaling pathway
• GPCR downstream signaling (Gq/11 and Gi/o)
Protein Summary
NMUR2 is a 415-amino acid G protein-coupled receptor with seven transmembrane domains. It binds neuromedin U with high affinity, activating phospholipase C via Gq/11 and inhibiting adenylyl cyclase via Gi/o. The receptor is critical for NMU-mediated effects on appetite suppression, stress axis regulation, and pain modulation. Structural studies suggest a conserved ligand-binding pocket in the transmembrane helices.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NMUR2 Knockout HEK293 Cell Line | EDJ-KQ51540 | Human | 56923 | Details Get a Quote |
| NMUR2 Knockout HeLa Cell Line | EDJ-KQ56768 | Human | 56923 | Details Get a Quote |
| NMUR2 Knockout A-549 Cell Line | EDJ-KQ65270 | Human | 56923 | Details Get a Quote |
| NMUR2 Knockout HCT 116 Cell Line | EDJ-KQ73713 | Human | 56923 | Details Get a Quote |
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