NCR3: Natural Cytotoxicity Triggering Receptor 3
Key activating receptor on natural killer cells involved in immune surveillance and tumor immunity
Gene Information Card
| Symbol | NCR3 |
|---|---|
| Full Name | Natural cytotoxicity triggering receptor 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 6p21.33 |
| NCBI Gene ID | 259197 ncbi.nlm.nih.gov/gene/259197 |
| Ensembl ID | ENSG00000204410 |
| UniProt ID | O14931 |
| OMIM ID | 611664 |
| HGNC ID | HGNC:16911 |
| Aliases | NKp30, 1C7, CD337, MALS, LY117 |
Description
NCR3 (natural cytotoxicity triggering receptor 3) encodes NKp30, an activating receptor expressed primarily on natural killer (NK) cells. It belongs to the immunoglobulin superfamily and mediates NK cell cytotoxicity and cytokine secretion upon binding to its ligands, including B7-H6 and BAT3. NCR3 plays a critical role in innate immune responses against tumors and infected cells.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | Reduced NCR3 expression impairs NK cell recognition of tumor cells | ClinVar, NCBI Gene |
| Acute myeloid leukemia | Soluble NKp30 levels correlate with disease progression and immune evasion | ClinVar, PubMed |
| HIV-1 infection | NCR3 polymorphisms associated with altered NK cell activity and viral load | OMIM, NCBI Gene |
| Rheumatoid arthritis | Dysregulated NKp30 expression contributes to autoimmune inflammation | ClinVar, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 12.5 | High |
| Peripheral blood | 8.3 | Medium |
| Lymph node | 7.1 | Medium |
| Bone marrow | 5.9 | Low |
| Lung | 2.4 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| NK-92 | 45.2 | High expression; model for NK cell studies |
| YTS | 38.7 | High expression; NK cell line |
| Jurkat | 1.3 | Very low; T-cell line |
| K562 | 0.8 | Not expressed; erythroleukemia line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs2736191 | SNP (intronic) | 0.12 (global) | Associated with altered NK cell activity |
| rs986475 | SNP (missense, p.Arg72His) | 0.08 (global) | Reduced ligand binding affinity |
| c.286_288del | Deletion (in-frame) | Rare | Loss of transmembrane domain; impaired surface expression |
Mutation functional classification
Loss of Function (LOF)
Missense variants (e.g., p.Arg72His) reduce ligand binding and NK cell activation; deletions in transmembrane domain abolish surface expression.
Gain of Function (GOF)
Not reported for NCR3.
Dominant Negative (DN)
Not reported for NCR3.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Natural killer cell mediated cytotoxicity (KEGG: hsa04650)
• Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Reactome: R-HSA-198933)
Protein Summary
NKp30 is a 30 kDa type I transmembrane glycoprotein with a single extracellular immunoglobulin-like domain. It associates with CD3ζ and FcεRIγ adaptor proteins to transduce activating signals. NKp30 recognizes tumor-associated ligands such as B7-H6 and BAT3, triggering NK cell degranulation and cytokine production. Soluble forms of NKp30 can modulate immune responses and are implicated in cancer prognosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NCR3 Knockout HEK293 Cell Line | EDJ-KQ14396 | Human | 259197 | Details Get a Quote |
| NCR3LG1 Knockout HEK293 Cell Line | EDJ-KQ14397 | Human | 374383 | Details Get a Quote |
| NCR3LG1 Knockout A-549 Cell Line | EDJ-KQ44575 | Human | 374383 | Details Get a Quote |
| NCR3LG1 Knockout HCT 116 Cell Line | EDJ-KQ44576 | Human | 374383 | Details Get a Quote |
| NCR3LG1 Knockout HeLa Cell Line | EDJ-KQ43323 | Human | 374383 | Details Get a Quote |
| NCR3 Knockout HeLa Cell Line | EDJ-KQ59330 | Human | 259197 | Details Get a Quote |
| NCR3 Knockout A-549 Cell Line | EDJ-KQ67792 | Human | 259197 | Details Get a Quote |
| NCR3 Knockout HCT 116 Cell Line | EDJ-KQ76177 | Human | 259197 | Details Get a Quote |
