NCR2 (NKp44): Natural Cytotoxicity Triggering Receptor 2
Key activating receptor on natural killer cells involved in immune surveillance and tumor immunity.
Gene Information Card
| Symbol | NCR2 |
|---|---|
| Full Name | Natural cytotoxicity triggering receptor 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 6p21.1 |
| NCBI Gene ID | 9436 ncbi.nlm.nih.gov/gene/9436 |
| Ensembl ID | ENSG00000124588 |
| UniProt ID | O95944 |
| OMIM ID | 604531 |
| HGNC ID | HGNC:7662 |
| Aliases | NKp44, LY95, CD336 |
Description
NCR2 (Natural Cytotoxicity Triggering Receptor 2) encodes NKp44, a transmembrane glycoprotein belonging to the natural cytotoxicity receptor (NCR) family. NKp44 is expressed primarily on activated natural killer (NK) cells and plays a critical role in NK cell-mediated cytotoxicity and cytokine production upon recognition of target cells. It binds to viral hemagglutinins and tumor-associated ligands, contributing to immune surveillance against infected and malignant cells.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Acute myeloid leukemia | NKp44-mediated recognition of leukemic blasts; altered expression may impair immune response | ClinVar, COSMIC |
| HIV infection | NKp44 expression is upregulated on NK cells; interaction with viral envelope proteins | NCBI Gene, UniProt |
| Influenza | NKp44 binds to hemagglutinin on infected cells, triggering NK cell activation | UniProt |
| Colorectal cancer | Reduced NCR2 expression correlates with poor prognosis and immune evasion | COSMIC, NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 0.6 | Low |
| Lung | 0.3 | Low |
| Bone marrow | 0.2 | Low |
| Whole blood | 0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| NK-92 | 12.5 | High expression; NK cell line |
| YTS | 8.2 | NK cell line |
| KHYG-1 | 9.1 | NK cell line |
| Jurkat | 0.1 | T cell line; minimal expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.614G>A (p.Arg205His) | Missense | <0.01% | Unknown functional effect |
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Potential loss of ligand binding |
Mutation functional classification
Loss of Function (LOF)
Missense variants in the ligand-binding domain may reduce receptor activation.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
Not described for NCR2.
View complete mutation data：
Gene Ontology (GO)
| • receptor activity (GO:0004872) | • signal transduction (GO:0007165) |
| • extracellular region (GO:0005576) | • integral component of membrane (GO:0016021) |
| • natural killer cell mediated cytotoxicity (GO:0042267) |
Pathways
• Natural killer cell mediated cytotoxicity (KEGG: hsa04650)
• Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Reactome: R-HSA-198933)
Protein Summary
NKp44 (O95944) is a 44 kDa type I transmembrane protein with a single extracellular immunoglobulin-like domain. It associates with DAP12 (TYROBP) adaptor protein to transduce activating signals via ITAM motifs. NKp44 recognizes ligands such as viral hemagglutinins and tumor-associated heparan sulfate proteoglycans, leading to NK cell degranulation and cytokine release.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NCR2 Knockout HEK293 Cell Line | EDJ-KQ6587 | Human | 9436 | Details Get a Quote |
| NCR2 Knockout HeLa Cell Line | EDJ-KQ55165 | Human | 9436 | Details Get a Quote |
| NCR2 Knockout A-549 Cell Line | EDJ-KQ63645 | Human | 9436 | Details Get a Quote |
| NCR2 Knockout HCT 116 Cell Line | EDJ-KQ72105 | Human | 9436 | Details Get a Quote |
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