NCOR1: Nuclear Receptor Corepressor 1
A key transcriptional coregulator in development, metabolism, and cancer
Gene Information Card
| Symbol | NCOR1 |
|---|---|
| Full Name | Nuclear Receptor Corepressor 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 17p11.2 |
| NCBI Gene ID | 9611 ncbi.nlm.nih.gov/gene/9611 |
| Ensembl ID | ENSG00000141027 |
| UniProt ID | O75376 |
| OMIM ID | 600849 |
| HGNC ID | 7672 |
| Aliases | KIAA1047, N-CoR, TRAC1, hN-CoR |
Description
NCOR1 encodes a nuclear receptor corepressor that mediates transcriptional repression by recruiting histone deacetylases (HDACs) to chromatin. It interacts with nuclear receptors such as retinoic acid receptor (RAR) and thyroid hormone receptor (TR), as well as other transcription factors. NCOR1 plays critical roles in development, metabolism, and immune regulation. Mutations and altered expression are implicated in various cancers and metabolic disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Acute myeloid leukemia | NCOR1 mutations impair transcriptional repression of genes involved in myeloid differentiation, contributing to leukemogenesis. | PMID: 21572415; COSMIC |
| Colorectal cancer | Loss-of-function mutations in NCOR1 disrupt HDAC recruitment, leading to aberrant gene expression and tumor progression. | PMID: 22980975; COSMIC |
| Breast cancer | NCOR1 downregulation correlates with poor prognosis and endocrine therapy resistance via altered estrogen receptor signaling. | PMID: 23104886; ClinVar |
| Obesity and metabolic syndrome | NCOR1 variants affect adipogenesis and energy homeostasis through PPARγ corepression. | PMID: 21572415; OMIM |
| Intellectual disability | Heterozygous NCOR1 deletions or missense mutations are associated with neurodevelopmental phenotypes. | PMID: 27616483; ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 15.2 | Medium |
| Kidney | 10.1 | Medium |
| Testis | 20.4 | High |
| Lung | 9.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 18.6 | High expression in embryonic kidney cells |
| HeLa | 14.2 | Moderate expression in cervical cancer cells |
| MCF7 | 11.5 | Moderate expression in breast cancer cells |
| K562 | 8.9 | Low expression in leukemia cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <1% | Loss of function; truncation of corepressor domain |
| c.567_568del (p.Glu190fs) | Frameshift | <1% | Loss of function; premature termination |
| c.2101G>A (p.Gly701Arg) | Missense | <0.5% | Impaired HDAC interaction; reduced repressive activity |
| c.3456+1G>A | Splice site | <0.5% | Splicing defect; loss of functional protein |
Mutation functional classification
Loss of Function (LOF)
Most NCOR1 mutations in cancer are loss-of-function, leading to derepression of target genes and promoting proliferation.
Gain of Function (GOF)
No well-characterized gain-of-function mutations reported.
Dominant Negative (DN)
Some missense mutations in the repression domains may act as dominant-negative by competing with wild-type NCOR1 for binding partners.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Nuclear receptor signaling pathway (RAR
• TR
• PPAR)
• Chromatin remodeling and histone deacetylation
• Notch signaling pathway
• Wnt signaling pathway
Protein Summary
NCOR1 is a 2440-amino acid nuclear protein that functions as a corepressor for multiple transcription factors. It contains three repression domains (RD1, RD2, RD3) that recruit HDAC complexes, and a nuclear receptor interaction domain (ID) that binds unliganded nuclear receptors. Through these interactions, NCOR1 silences gene expression in the absence of activating signals. Its dysregulation is linked to cancer, metabolic disease, and developmental disorders.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NCOR1 Knockout HEK293 Cell Line | EDJ-KQ6658 | Human | 9611 | Details Get a Quote |
| NCOR1 Knockout A-549 Cell Line | EDJ-KQ30954 | Human | 9611 | Details Get a Quote |
| NCOR1 Knockout HCT 116 Cell Line | EDJ-KQ30955 | Human | 9611 | Details Get a Quote |
| NCOR1 Knockout HeLa Cell Line | EDJ-KQ30956 | Human | 9611 | Details Get a Quote |
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