NACA2 Gene - Nascent Polypeptide Associated Complex Subunit Alpha 2
Comprehensive genomic and proteomic analysis of NACA2, a transcriptional coactivator and ribosome-associated chaperone.
Gene Information Card
| Symbol | NACA2 |
|---|---|
| Full Name | Nascent Polypeptide Associated Complex Subunit Alpha 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 17q23.2 |
| NCBI Gene ID | 342538 ncbi.nlm.nih.gov/gene/342538 |
| Ensembl ID | ENSG00000187772 |
| UniProt ID | Q9H009 |
| OMIM ID | 617135 |
| HGNC ID | 24867 |
| Aliases | NACA2, NACA2P, NACA2L, NACA2-like |
Description
NACA2 (Nascent Polypeptide Associated Complex Subunit Alpha 2) encodes a protein that is a member of the nascent polypeptide-associated complex (NAC) family. This protein functions as a transcriptional coactivator and ribosome-associated chaperone, involved in protein targeting and folding. NACA2 is located on chromosome 17q23.2 and is expressed in multiple tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | No curated disease entries in OMIM, ClinVar, or COSMIC as of current data. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Brain | 8.7 | Low |
| Heart | 6.2 | Low |
| Liver | 5.1 | Low |
| Kidney | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.2 | Moderate expression |
| HeLa | 10.5 | Low expression |
| K562 | 8.9 | Low expression |
| MCF7 | 7.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
Pathways
• Ribosome (KEGG hsa03010)
• Protein processing in endoplasmic reticulum (KEGG hsa04141)
• Nonsense-mediated decay (Reactome R-HSA-927802)
Protein Summary
The NACA2 protein (UniProt Q9H009) is a 215-amino acid polypeptide with a molecular mass of approximately 24 kDa. It contains a NAC domain and is localized to the cytoplasm and nucleus. NACA2 binds to ribosomes and nascent polypeptide chains, facilitating proper protein folding and targeting. It also acts as a transcriptional coactivator by interacting with transcription factors.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NACA2 Knockout HEK293 Cell Line | EDJ-KQ14361 | Human | 342538 | Details Get a Quote |
| NACA2 Knockout A-549 Cell Line | EDJ-KQ44492 | Human | 342538 | Details Get a Quote |
| NACA2 Knockout HeLa Cell Line | EDJ-KQ44493 | Human | 342538 | Details Get a Quote |
| NACA2 Knockout HCT 116 Cell Line | EDJ-KQ43258 | Human | 342538 | Details Get a Quote |
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