MYT1: Myelin Transcription Factor 1
A zinc finger transcription factor involved in neurogenesis and oligodendrocyte differentiation
Gene Information Card
| Symbol | MYT1 |
|---|---|
| Full Name | Myelin Transcription Factor 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 20q13.33 |
| NCBI Gene ID | 4661 ncbi.nlm.nih.gov/gene/4661 |
| Ensembl ID | ENSG00000101247 |
| UniProt ID | Q01538 |
| OMIM ID | 600379 |
| HGNC ID | 7622 |
| Aliases | MTF1, ZC2H2C1, NZF1, ST18 |
Description
MYT1 (myelin transcription factor 1) encodes a zinc finger protein that acts as a transcriptional repressor. It is essential for central nervous system development, particularly in the differentiation of oligodendrocytes and the formation of myelin sheaths. MYT1 is also expressed in testis and certain neural progenitor cells. Mutations and altered expression have been implicated in neurodevelopmental disorders and cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Neurodevelopmental disorder with or without seizures | Loss-of-function mutations impair oligodendrocyte differentiation and neuronal migration | ClinVar |
| Glioblastoma | Overexpression of MYT1 promotes tumor cell proliferation and invasion | COSMIC |
| Testicular germ cell tumors | MYT1 expression is upregulated and associated with poor prognosis | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Testis | 8.3 | Low |
| Spinal cord | 6.1 | Low |
| Cerebellum | 10.2 | Medium |
| Cerebral cortex | 14.7 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 18.4 | High expression in neuronal-like cells |
| U87MG (glioblastoma) | 22.1 | Overexpressed compared to normal astrocytes |
| HEK293 (embryonic kidney) | 3.2 | Low endogenous expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1123C>T (p.Arg375Ter) | Nonsense | Rare | Loss of function; truncation of zinc finger domain |
| c.1456G>A (p.Gly486Ser) | Missense | Unknown | Likely damaging; alters DNA-binding affinity |
| c.1789_1791del (p.Phe597del) | In-frame deletion | Rare | Disrupts protein stability and repressor activity |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations leading to truncated protein lacking functional zinc finger domains; associated with neurodevelopmental disorders.
Gain of Function (GOF)
Not well documented; overexpression in glioblastoma may confer oncogenic properties.
Dominant Negative (DN)
Not reported for MYT1.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Oligodendrocyte specification and differentiation (REACT:R-HSA-9617324)
• Transcriptional regulation by MYT1 (REACT:R-HSA-212436)
Protein Summary
MYT1 is a 1,123-amino acid zinc finger transcription factor containing multiple C2HC-type zinc fingers. It localizes to the nucleus and functions primarily as a transcriptional repressor. MYT1 is critical for the maturation of oligodendrocyte progenitor cells into myelinating oligodendrocytes. It also plays roles in neuronal survival and testicular development. The protein interacts with other transcription factors such as SOX10 and OLIG2 to coordinate myelin gene expression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MYT1 Knockout HEK293 Cell Line | EDJ-KQ2740 | Human | 4661 | Details Get a Quote |
| MYT1L Knockout HEK293 Cell Line | EDJ-KQ7787 | Human | 23040 | Details Get a Quote |
| MYT1 Knockout A-549 Cell Line | EDJ-KQ23615 | Human | 4661 | Details Get a Quote |
| MYT1 Knockout HCT 116 Cell Line | EDJ-KQ23616 | Human | 4661 | Details Get a Quote |
| MYT1 Knockout HeLa Cell Line | EDJ-KQ53957 | Human | 4661 | Details Get a Quote |
| MYT1L Knockout HeLa Cell Line | EDJ-KQ55679 | Human | 23040 | Details Get a Quote |
| MYT1L Knockout A-549 Cell Line | EDJ-KQ64178 | Human | 23040 | Details Get a Quote |
| MYT1L Knockout HCT 116 Cell Line | EDJ-KQ72620 | Human | 23040 | Details Get a Quote |
Displaying Records 1 To 8 Of 8 Records
