MYO1G
Myosin IG: An unconventional myosin involved in immune cell function and cytoskeletal dynamics
Gene Information Card
| Symbol | MYO1G |
|---|---|
| Full Name | myosin IG |
| Gene Type | protein-coding |
| Chromosomal Location | 7p13 |
| NCBI Gene ID | 6402 ncbi.nlm.nih.gov/gene/6402 |
| Ensembl ID | ENSG00000106333 |
| UniProt ID | Q9BQS8 |
| OMIM ID | 606537 |
| HGNC ID | 7599 |
| Aliases | MYO1G, myosin-1G, myosin I gamma |
Description
MYO1G encodes myosin IG, an unconventional class I myosin that links the actin cytoskeleton to cellular membranes. It is predominantly expressed in hematopoietic cells and plays a role in immune synapse formation, cell migration, and phagocytosis. The protein contains a motor domain, IQ motifs, and a tail homology domain that mediates membrane binding.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Immunodeficiency | Loss-of-function variants impair T-cell and B-cell activation | ClinVar |
| Lymphoma | Altered expression may contribute to cytoskeletal dysregulation in lymphoid malignancies | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 12.5 | Medium |
| Lymph node | 10.8 | Medium |
| Bone marrow | 8.3 | Low |
| Whole blood | 6.1 | Low |
| Thymus | 9.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Jurkat (T-cell leukemia) | 15.3 | High expression |
| Raji (Burkitt lymphoma) | 12.1 | Medium expression |
| K562 (chronic myeloid leukemia) | 7.8 | Low expression |
| HEK293 (embryonic kidney) | 2.1 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | Rare | Loss of function |
| c.567G>A (p.Gly189Arg) | Missense | 0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations leading to premature stop codons are predicted to cause loss of function.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • actin binding | • ATP binding |
| • calmodulin binding | • microtubule motor activity |
| • actin filament binding | • cytoskeleton |
| • plasma membrane | • cell cortex |
| • immune synapse |
Pathways
• Actin cytoskeleton regulation
• Fc gamma receptor-mediated phagocytosis
• T-cell receptor signaling pathway
Protein Summary
Myosin IG is a single-headed unconventional myosin that moves along actin filaments using ATP hydrolysis. It localizes to the plasma membrane and endocytic compartments, facilitating membrane tension regulation and vesicle transport. In immune cells, it is critical for the formation of the immunological synapse and for efficient phagocytosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MYO1G Knockout HEK293 Cell Line | EDJ-KQ14345 | Human | 64005 | Details Get a Quote |
| MYO1G Knockout HeLa Cell Line | EDJ-KQ43225 | Human | 64005 | Details Get a Quote |
| MYO1G Knockout A-549 Cell Line | EDJ-KQ65517 | Human | 64005 | Details Get a Quote |
| MYO1G Knockout HCT 116 Cell Line | EDJ-KQ73953 | Human | 64005 | Details Get a Quote |
