MYO16 (Myosin XVI)
Gene encoding an unconventional myosin involved in neuronal development and potential tumor suppression
Gene Information Card
| Symbol | MYO16 |
|---|---|
| Full Name | myosin XVI |
| Gene Type | protein coding |
| Chromosomal Location | 13q33.3 |
| NCBI Gene ID | 23026 ncbi.nlm.nih.gov/gene/23026 |
| Ensembl ID | ENSG00000141510 |
| UniProt ID | Q9Y6X9 |
| OMIM ID | 609929 |
| HGNC ID | 7603 |
| Aliases | MYR8, NYAP3, KIAA0865 |
Description
MYO16 encodes myosin XVI, an unconventional myosin motor protein that binds actin filaments and is implicated in neuronal morphogenesis, including neurite outgrowth and dendritic spine formation. It contains an N-terminal PH domain and a C-terminal MyTH4-FERM domain, and is thought to function in intracellular transport and signaling. MYO16 is also known as NYAP3 (Neuronal Tyrosine-phosphorylated Adaptor for PI3K) and may play a role in tumor suppression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Potential tumor suppressor; reduced expression correlates with poor prognosis | PMID: 23468909 |
| Glioblastoma | Altered expression linked to tumor progression | PMID: 25691885 |
| Intellectual disability | Rare variants identified in patients with neurodevelopmental disorders | PMID: 27545674 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Testis | 8.3 | Low |
| Lung | 4.1 | Low |
| Kidney | 3.2 | Low |
| Liver | 1.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 15.2 | Neuronal model |
| U87MG (glioblastoma) | 9.8 | Glial tumor line |
| MCF7 (breast cancer) | 2.1 | Low expression |
| HEK293 (embryonic kidney) | 1.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <0.1% | Loss of function |
| c.4567G>A (p.Glu1523Lys) | Missense | 0.2% | Unknown |
| c.7890_7891insA | Frameshift | <0.1% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift variants predicted to truncate the protein, likely leading to loss of motor or adaptor function.
Gain of Function (GOF)
No documented gain-of-function mutations.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • actin binding | • ATP binding |
| • microtubule motor activity | • phosphatidylinositol-3 |
| • 4 | • 5-trisphosphate binding |
| • neuronal cell body | • dendrite |
| • axon | • cytoplasm |
Pathways
• PI3K-Akt signaling pathway
• Neuronal development
• Actin cytoskeleton regulation
Protein Summary
Myosin XVI is a 2148-amino-acid unconventional myosin with a motor domain, a PH domain, and a MyTH4-FERM tail. It localizes to actin-rich structures in neurons and interacts with PI3K to regulate cell growth and migration. The protein is predominantly expressed in brain and testis, with lower levels in other tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MYO16 Knockout HEK293 Cell Line | EDJ-KQ7092 | Human | 23026 | Details Get a Quote |
| MYO16 Knockout HeLa Cell Line | EDJ-KQ55677 | Human | 23026 | Details Get a Quote |
| MYO16 Knockout A-549 Cell Line | EDJ-KQ64174 | Human | 23026 | Details Get a Quote |
| MYO16 Knockout HCT 116 Cell Line | EDJ-KQ72617 | Human | 23026 | Details Get a Quote |
