MYO10: Myosin X - A Key Regulator of Filopodia Formation and Cell Migration
Comprehensive gene card for MYO10, including genomic annotations, expression profiles, disease associations, and functional classifications.
Gene Information Card
| Symbol | MYO10 |
|---|---|
| Full Name | myosin X |
| Gene Type | protein-coding |
| Chromosomal Location | 5p15.1 |
| NCBI Gene ID | 4655 ncbi.nlm.nih.gov/gene/4655 |
| Ensembl ID | ENSG00000145555 |
| UniProt ID | Q9HD67 |
| OMIM ID | 601481 |
| HGNC ID | 7596 |
| Aliases | KIAA0745, Myo10, myosin-X |
Description
MYO10 encodes myosin X, an unconventional myosin motor protein that binds actin filaments and plays a critical role in filopodia formation, cell migration, and adhesion. It localizes to the tips of filopodia and mediates integrin-based signaling. MYO10 is implicated in cancer metastasis and developmental processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | MYO10 overexpression promotes filopodia formation and cell migration, contributing to metastatic potential. | COSMIC; multiple studies in PubMed |
| Intellectual disability (candidate) | Rare MYO10 variants may disrupt neuronal migration or filopodia dynamics. | ClinVar; limited evidence |
| Hearing loss (candidate) | MYO10 expression in inner ear hair cells suggests a role in stereocilia formation. | OMIM; animal models |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Kidney | 15.2 | Medium |
| Testis | 22.1 | High |
| Placenta | 18.7 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.5 | Cervical cancer cell line |
| A549 | 9.8 | Lung cancer cell line |
| MCF7 | 11.2 | Breast cancer cell line |
| HEK293 | 16.3 | Embryonic kidney cell line |
| SH-SY5Y | 20.1 | Neuroblastoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Cys) | Missense | <0.01% | Unknown; predicted damaging by SIFT |
| c.2567_2568del (p.Leu856fs) | Frameshift | <0.01% | Loss of function; likely pathogenic |
| c.3456G>A (p.Trp1152*) | Nonsense | <0.01% | Loss of function; truncation |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations in MYO10 are predicted to cause loss of motor function, impairing filopodia formation.
Gain of Function (GOF)
Not well documented; overexpression in cancer may act as a gain-of-function by enhancing cell migration.
Dominant Negative (DN)
Missense mutations in the motor domain may interfere with wild-type myosin X function, but evidence is limited.
View complete mutation data：
Gene Ontology (GO)
| • actin binding | • ATP binding |
| • microtubule motor activity | • filopodium |
| • cell migration | • integrin binding |
Pathways
• Regulation of actin cytoskeleton (KEGG: hsa04810)
• Focal adhesion (KEGG: hsa04510)
• Filopodia formation (Reactome: R-HSA-2029481)
Protein Summary
Myosin X is a 240 kDa unconventional myosin with a motor domain, IQ motifs, a coiled-coil region, and a FERM domain. It transports cargo along actin filaments to the tips of filopodia, where it regulates integrin recycling and signaling. The FERM domain mediates interactions with membrane proteins such as integrins and DCC.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MYO10 Knockout HEK293 Cell Line | EDJ-KQ4511 | Human | 4651 | Details Get a Quote |
| MYO10 Knockout A-549 Cell Line | EDJ-KQ28345 | Human | 4651 | Details Get a Quote |
| MYO10 Knockout HCT 116 Cell Line | EDJ-KQ28346 | Human | 4651 | Details Get a Quote |
| MYO10 Knockout HeLa Cell Line | EDJ-KQ28347 | Human | 4651 | Details Get a Quote |
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