MYH10: Myosin Heavy Chain 10 - A Key Cytoskeletal Motor Protein
Comprehensive genomic, transcriptomic, and proteomic analysis of MYH10, including expression, mutations, and disease associations.
Gene Information Card
| Symbol | MYH10 |
|---|---|
| Full Name | Myosin Heavy Chain 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 17p13.1 |
| NCBI Gene ID | 4628 ncbi.nlm.nih.gov/gene/4628 |
| Ensembl ID | ENSG00000133026 |
| UniProt ID | P35580 |
| OMIM ID | 160776 |
| HGNC ID | 7568 |
| Aliases | NMHC IIB, NMMHC IIB, MGC134872 |
Description
MYH10 encodes the heavy chain of non-muscle myosin IIB, a member of the myosin superfamily. This protein is a major component of the cytoskeleton, involved in cell motility, adhesion, cytokinesis, and tissue morphogenesis. It functions as an actin-based motor ATPase, generating contractile force. Mutations and altered expression of MYH10 are associated with various cancers, developmental disorders, and cardiovascular diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hereditary nonpolyposis colorectal cancer (Lynch syndrome) | MYH10 interacts with mismatch repair proteins; loss of expression may contribute to microsatellite instability. | ClinVar, COSMIC |
| Breast cancer | Overexpression of MYH10 correlates with poor prognosis; promotes cell migration and invasion. | COSMIC, NCBI PubMed |
| Cardiomyopathy, dilated | MYH10 variants disrupt sarcomere organization and contractile function. | OMIM, ClinVar |
| Developmental brain malformations | MYH10 mutations impair neuronal migration and cortical development. | OMIM, ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 18.5 | High |
| Heart | 15.2 | High |
| Lung | 12.8 | Medium |
| Liver | 8.1 | Medium |
| Kidney | 10.3 | Medium |
| Skeletal muscle | 6.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 22.4 | Cervical cancer cell line; high expression |
| MCF7 | 18.9 | Breast cancer cell line; moderate expression |
| A549 | 15.6 | Lung cancer cell line; moderate expression |
| HEK293 | 12.3 | Embryonic kidney; moderate expression |
| K562 | 9.8 | Leukemia cell line; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.4537C>T (p.Arg1513Trp) | Missense | <0.01% | Altered ATPase activity; associated with dilated cardiomyopathy |
| c.2101G>A (p.Glu701Lys) | Missense | <0.01% | Impaired actin binding; linked to developmental brain malformations |
| c.1234_1235insA (p.Thr412Asnfs*5) | Frameshift | <0.01% | Loss of function; observed in colorectal cancer |
| c.2890A>G (p.Thr964Ala) | Missense | <0.01% | Unknown significance; reported in COSMIC |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations leading to truncated protein or nonsense-mediated decay; associated with cancer and developmental defects.
Gain of Function (GOF)
Missense mutations that enhance ATPase activity or actin binding, potentially promoting cell migration in cancer.
Dominant Negative (DN)
Missense mutations that disrupt filament assembly or motor function, interfering with wild-type myosin IIB activity.
View complete mutation data：
Gene Ontology (GO)
Pathways
• REACT:21333 - Smooth muscle contraction
• REACT:21334 - Non-muscle myosin II signaling
• REACT:21335 - Actin cytoskeleton regulation
• REACT:21336 - Cell migration and adhesion
Protein Summary
Myosin heavy chain 10 (MYH10) is a 1960-amino acid protein that forms the heavy chain of non-muscle myosin IIB. It contains an N-terminal motor domain with ATPase activity, a neck region with IQ motifs for light chain binding, and a C-terminal tail domain involved in filament assembly. The protein is ubiquitously expressed, with highest levels in brain and heart. It plays critical roles in cytokinesis, cell polarity, and tissue integrity. Post-translational modifications include phosphorylation of the regulatory light chain, which controls its activity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MYH10 Knockout HEK293 Cell Line | EDJ-KQ2734 | Human | 4628 | Details Get a Quote |
| MYH10 Knockout HeLa Cell Line | EDJ-KQ22231 | Human | 4628 | Details Get a Quote |
| MYH10 Knockout A-549 Cell Line | EDJ-KQ23601 | Human | 4628 | Details Get a Quote |
| MYH10 Knockout HCT 116 Cell Line | EDJ-KQ23602 | Human | 4628 | Details Get a Quote |
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