MYADML2
Myeloid-Associated Differentiation Marker-Like 2
Gene Information Card
| Symbol | MYADML2 |
|---|---|
| Full Name | Myeloid-Associated Differentiation Marker-Like 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 17q21.31 |
| NCBI Gene ID | 255275 ncbi.nlm.nih.gov/gene/255275 |
| Ensembl ID | ENSG00000187608 |
| UniProt ID | Q5VU43 |
| OMIM ID | 617447 |
| HGNC ID | 33736 |
| Aliases | MGC26733, FLJ39653 |
Description
MYADML2 (Myeloid-Associated Differentiation Marker-Like 2) is a protein-coding gene located on chromosome 17q21.31. It encodes a protein of unknown function, but based on sequence similarity it is related to the MYADM family involved in myeloid differentiation. Expression data suggest roles in specific tissues and cell types.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not established | No evidence in OMIM, ClinVar, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lung | 5.2 | Low |
| Spleen | 3.8 | Low |
| Bone marrow | 2.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 | 8.0 | Leukemia cell line |
| HeLa | 4.5 | Cervical carcinoma |
| HEK 293 | 3.0 | Embryonic kidney |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Protein Summary
The MYADML2 protein (UniProt Q5VU43) is 247 amino acids long and contains a MYADM-like domain. Its exact function is unknown, but it may be involved in cell differentiation processes.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MYADML2 Knockout HEK293 Cell Line | EDJ-KQ11792 | Human | 255275 | Details Get a Quote |
| MYADML2 Knockout HeLa Cell Line | EDJ-KQ59277 | Human | 255275 | Details Get a Quote |
| MYADML2 Knockout A-549 Cell Line | EDJ-KQ67743 | Human | 255275 | Details Get a Quote |
| MYADML2 Knockout HCT 116 Cell Line | EDJ-KQ76128 | Human | 255275 | Details Get a Quote |
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