MYADM (Myeloid-Associated Differentiation Marker)
A transmembrane protein involved in cell adhesion, migration, and potential roles in cancer and immune regulation.
Gene Information Card
| Symbol | MYADM |
|---|---|
| Full Name | Myeloid-Associated Differentiation Marker |
| Gene Type | Protein coding |
| Chromosomal Location | 19q13.42 |
| NCBI Gene ID | 91663 ncbi.nlm.nih.gov/gene/91663 |
| Ensembl ID | ENSG00000105329 |
| UniProt ID | Q96S97 |
| OMIM ID | 609886 |
| HGNC ID | 29627 |
| Aliases | SB135, MYADM |
Description
MYADM encodes a transmembrane protein that is upregulated during myeloid differentiation. It is involved in cell adhesion, migration, and cytoskeletal organization. The protein localizes to the plasma membrane and may play a role in hematopoietic cell maturation and cancer progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Acute Myeloid Leukemia | Potential role in differentiation block; altered expression | NCBI Gene, PubMed |
| Breast Cancer | Overexpression associated with metastasis and poor prognosis | NCBI Gene, PubMed |
| Colorectal Cancer | Upregulation linked to tumor progression | NCBI Gene, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone Marrow | 12.5 | Medium |
| Lung | 8.3 | Low |
| Spleen | 10.1 | Medium |
| Liver | 6.7 | Low |
| Kidney | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HL-60 (leukemia) | 15.2 | Myeloid differentiation model |
| MCF-7 (breast cancer) | 9.8 | Epithelial cancer line |
| A549 (lung cancer) | 7.1 | Lung adenocarcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.200C>T (p.Pro67Leu) | Missense | <0.1% | Unknown; not in COSMIC |
| c.415G>A (p.Val139Met) | Missense | <0.1% | Unknown; not in COSMIC |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • plasma membrane (GO:0005886) | • cell adhesion (GO:0007155) |
| • cell migration (GO:0016477) | • cell differentiation (GO:0030154) |
Pathways
• No specific pathways curated in Reactome or KEGG for MYADM.
Protein Summary
MYADM is a 249-amino acid transmembrane protein with a single transmembrane domain. It is expressed in hematopoietic tissues and various cancers, where it may regulate cell adhesion and migration through interactions with the cytoskeleton. Its exact molecular function remains under investigation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MYADM Knockout HEK293 Cell Line | EDJ-KQ10769 | Human | 91663 | Details Get a Quote |
| MYADML2 Knockout HEK293 Cell Line | EDJ-KQ11792 | Human | 255275 | Details Get a Quote |
| MYADM Knockout A-549 Cell Line | EDJ-KQ37086 | Human | 91663 | Details Get a Quote |
| MYADM Knockout HCT 116 Cell Line | EDJ-KQ38381 | Human | 91663 | Details Get a Quote |
| MYADM Knockout HeLa Cell Line | EDJ-KQ38382 | Human | 91663 | Details Get a Quote |
| MYADML2 Knockout HeLa Cell Line | EDJ-KQ59277 | Human | 255275 | Details Get a Quote |
| MYADML2 Knockout A-549 Cell Line | EDJ-KQ67743 | Human | 255275 | Details Get a Quote |
| MYADML2 Knockout HCT 116 Cell Line | EDJ-KQ76128 | Human | 255275 | Details Get a Quote |
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