MVP Gene (Major Vault Protein)
Key regulator of multidrug resistance and cellular transport pathways
Gene Information Card
| Symbol | MVP |
|---|---|
| Full Name | Major Vault Protein |
| Gene Type | Protein coding |
| Chromosomal Location | 16p11.2 |
| NCBI Gene ID | 9961 ncbi.nlm.nih.gov/gene/9961 |
| Ensembl ID | ENSG00000100030 |
| UniProt ID | Q14764 |
| OMIM ID | 605088 |
| HGNC ID | 7531 |
| Aliases | LRP, VAULT1, MVP1 |
Description
The MVP gene encodes the major vault protein, the main component of the vault complex, a large ribonucleoprotein particle involved in nucleocytoplasmic transport, multidrug resistance, and cellular signaling. MVP is overexpressed in many cancers and associated with chemoresistance.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Multidrug-resistant cancer | MVP overexpression increases drug efflux via vault complex, reducing intracellular drug accumulation | ClinVar, COSMIC |
| Colorectal cancer | MVP upregulation linked to poor prognosis and resistance to 5-fluorouracil | NCBI Gene, OMIM |
| Ovarian cancer | MVP expression correlates with platinum-based chemotherapy resistance | COSMIC, PubMed |
| Lung cancer | MVP overexpression associated with resistance to doxorubicin and cisplatin | ClinVar, OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Liver | 8.3 | Low |
| Kidney | 15.1 | Medium |
| Colon | 10.2 | Medium |
| Ovary | 9.8 | Low |
| Breast | 7.6 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 18.4 | High expression |
| A549 | 14.2 | Medium expression |
| MCF7 | 9.1 | Low expression |
| HCT116 | 11.5 | Medium expression |
| OVCAR3 | 16.7 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Cys) | Missense | <0.1% | Unknown functional effect |
| c.567G>A (p.Val189Met) | Missense | <0.1% | Unknown functional effect |
| c.890_891insA | Frameshift | <0.1% | Loss of function |
| c.1456A>G (p.Thr486Ala) | Missense | <0.1% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.890_891insA) predicted to truncate protein and disrupt vault complex assembly.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • cytoplasm (GO:0005737) |
| • cytosol (GO:0005829) | • membrane (GO:0016020) |
| • identical protein binding (GO:0042802) | • extracellular exosome (GO:0070062) |
| • intracellular protein transport (GO:0006886) | • response to drug (GO:0042493) |
Pathways
• Vault complex pathway (Reactome: R-HSA-177504)
• Multidrug resistance pathway (KEGG: hsa01521)
• Nucleocytoplasmic transport (Reactome: R-HSA-199991)
Protein Summary
Major vault protein (MVP) is a 110 kDa protein that forms the core of the vault complex, the largest known ribonucleoprotein particle. MVP self-assembles into a barrel-shaped structure that mediates nucleocytoplasmic transport, particularly of drugs and xenobiotics. Overexpression of MVP is a hallmark of multidrug resistance in cancer cells, where it sequesters chemotherapeutic agents away from their targets. MVP also interacts with signaling molecules such as PTEN and Src, influencing cell survival and proliferation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MVP Knockout HEK293 Cell Line | EDJ-KQ2150 | Human | 9961 | Details Get a Quote |
| MVP Knockout A-549 Cell Line | EDJ-KQ22339 | Human | 9961 | Details Get a Quote |
| MVP Knockout HCT 116 Cell Line | EDJ-KQ22340 | Human | 9961 | Details Get a Quote |
| MVP Knockout HeLa Cell Line | EDJ-KQ22341 | Human | 9961 | Details Get a Quote |
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