MUC15: Mucin 15, Cell Surface Associated
A transmembrane mucin involved in epithelial barrier function and cancer progression
Gene Information Card
| Symbol | MUC15 |
|---|---|
| Full Name | Mucin 15, Cell Surface Associated |
| Gene Type | Protein coding |
| Chromosomal Location | 11p14.2 |
| NCBI Gene ID | 143662 ncbi.nlm.nih.gov/gene/143662 |
| Ensembl ID | ENSG00000176444 |
| UniProt ID | Q8N387 |
| OMIM ID | 610088 |
| HGNC ID | 16856 |
| Aliases | MUC-15, MUC15_HUMAN |
Description
MUC15 encodes a member of the mucin family, a group of high-molecular-weight glycoproteins that are major components of mucus. MUC15 is a transmembrane mucin expressed on the apical surface of epithelial cells, where it contributes to the protective mucus barrier, cell signaling, and adhesion. It is involved in various cancers, where altered expression can influence tumor progression and metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | Altered MUC15 expression affects cell adhesion and signaling pathways, promoting invasion and metastasis. | NCBI Gene, COSMIC |
| Gastric Cancer | MUC15 overexpression correlates with poor prognosis and may enhance tumor cell proliferation. | NCBI Gene, COSMIC |
| Breast Cancer | MUC15 is upregulated in some breast cancer subtypes and may contribute to metastatic potential. | NCBI Gene, COSMIC |
| Lung Cancer | MUC15 expression changes are associated with tumor progression and patient survival. | NCBI Gene, COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Stomach | 8.3 | Medium |
| Colon | 6.7 | Low |
| Breast | 5.2 | Low |
| Kidney | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (Lung) | 15.0 | High expression |
| MCF7 (Breast) | 7.5 | Moderate expression |
| HT-29 (Colon) | 6.0 | Low expression |
| HeLa (Cervical) | 3.2 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T | Missense | <0.1% | p.Pro412Ser; unknown significance |
| c.567G>A | Missense | <0.1% | p.Val189Met; unknown significance |
| c.890_891insA | Frameshift | <0.1% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.890_891insA) are predicted to truncate the protein, disrupting the transmembrane domain and mucin function.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • extracellular region | • plasma membrane |
| • integral component of membrane | • protein binding |
| • O-glycan processing |
Pathways
• Mucin-type O-glycan biosynthesis (KEGG:00512)
• Cell adhesion molecules (CAMs)
Protein Summary
MUC15 is a transmembrane mucin glycoprotein with a large extracellular domain rich in serine and threonine residues that undergo O-glycosylation. It forms a protective barrier on epithelial surfaces and participates in cell-cell and cell-matrix interactions. The protein has a single transmembrane domain and a short cytoplasmic tail that may be involved in intracellular signaling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MUC15 Knockout HEK293 Cell Line | EDJ-KQ10390 | Human | 143662 | Details Get a Quote |
| MUC15 Knockout HeLa Cell Line | EDJ-KQ58492 | Human | 143662 | Details Get a Quote |
| MUC15 Knockout A-549 Cell Line | EDJ-KQ66981 | Human | 143662 | Details Get a Quote |
| MUC15 Knockout HCT 116 Cell Line | EDJ-KQ75380 | Human | 143662 | Details Get a Quote |
