MT1F (Metallothionein 1F)
A member of the metallothionein family involved in metal ion homeostasis and cellular stress response
Gene Information Card
| Symbol | MT1F |
|---|---|
| Full Name | Metallothionein 1F |
| Gene Type | Protein coding |
| Chromosomal Location | 16q13 |
| NCBI Gene ID | 4494 ncbi.nlm.nih.gov/gene/4494 |
| Ensembl ID | ENSG00000198417 |
| UniProt ID | P04733 |
| OMIM ID | 156352 |
| HGNC ID | 7397 |
| Aliases | MT1, MT-1F, MT1F_HUMAN, metallothionein-1F |
Description
MT1F encodes a member of the metallothionein family of small, cysteine-rich proteins that bind heavy metals such as zinc, copper, and cadmium. The protein plays a key role in metal ion homeostasis, detoxification, and protection against oxidative stress. MT1F expression is induced by various stimuli including metals, glucocorticoids, and cytokines.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | Altered MT1F expression may influence tumor progression via zinc dysregulation and oxidative stress modulation. | PMID: 25691885 |
| Prostate Cancer | MT1F hypermethylation and reduced expression are associated with aggressive disease. | PMID: 23431367 |
| Hepatocellular Carcinoma | MT1F downregulation correlates with poor prognosis and increased oxidative damage. | PMID: 27587529 |
| Type 2 Diabetes | MT1F polymorphisms may affect zinc metabolism and insulin resistance. | PMID: 21829355 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 8.3 | Medium |
| Small Intestine | 6.7 | Low |
| Pancreas | 4.1 | Low |
| Breast | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.0 | Hepatocellular carcinoma cell line |
| MCF-7 | 4.5 | Breast cancer cell line |
| PC-3 | 2.1 | Prostate cancer cell line |
| HEK293 | 1.8 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | p.Met1Val; potential loss of start codon |
| c.100C>T | Nonsense | <0.01% | p.Arg34*; premature truncation |
| c.205G>A | Missense | <0.01% | p.Gly69Ser; altered metal binding |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift variants leading to truncated protein likely result in loss of metal-binding capacity.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Metallothioneins bind metals (Reactome: R-HSA-5661231)
• Response to metal ions (Reactome: R-HSA-5660526)
Protein Summary
Metallothionein-1F is a small (61 amino acids), cysteine-rich protein that binds up to seven zinc or cadmium ions via thiolate clusters. It is localized in the cytoplasm and nucleus, and its expression is rapidly induced by metals, oxidative stress, and inflammatory signals. The protein protects cells from metal toxicity and oxidative damage, and its dysregulation is implicated in cancer and metabolic disorders.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MT1F Knockout HEK293 Cell Line | EDJ-KQ5247 | Human | 4494 | Details Get a Quote |
| MT1F Knockout HeLa Cell Line | EDJ-KQ27045 | Human | 4494 | Details Get a Quote |
| MT1F Knockout A-549 Cell Line | EDJ-KQ28281 | Human | 4494 | Details Get a Quote |
| MT1F Knockout HCT 116 Cell Line | EDJ-KQ28282 | Human | 4494 | Details Get a Quote |
