MRGPRD (Mas-Related G Protein-Coupled Receptor D)
A sensory neuron-enriched GPCR implicated in itch, pain, and potential therapeutic targeting
Gene Information Card
| Symbol | MRGPRD |
|---|---|
| Full Name | MAS-related GPR, member D |
| Gene Type | protein-coding |
| Chromosomal Location | 11p15.1 |
| NCBI Gene ID | 259249 ncbi.nlm.nih.gov/gene/259249 |
| Ensembl ID | ENSG00000172985 |
| UniProt ID | Q8TDS7 |
| OMIM ID | 607240 |
| HGNC ID | 29698 |
| Aliases | MRGD, TGR7, GPR105 |
Description
MRGPRD encodes a G protein-coupled receptor (GPCR) that is predominantly expressed in a subset of dorsal root ganglion (DRG) neurons, specifically non-peptidergic nociceptors. It is activated by beta-alanine and is involved in the modulation of itch and pain signaling. MRGPRD has been implicated in the development of sensory neuron subtypes and is a potential target for analgesic and antipruritic therapies.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Not directly associated with a specific disease | MRGPRD is primarily studied in the context of sensory neuron function; no germline disease-causing mutations have been reported in OMIM or ClinVar. | No direct disease association; functional studies in animal models. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Dorsal Root Ganglion | Not available (nTPM not provided by GTEx) | High expression in DRG neurons (RNA-seq and protein studies) |
| Skin | Not available | Low expression; mainly in nerve fibers |
| Spinal Cord | Not available | Low expression; in central terminals of DRG neurons |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 (transfected) | Not applicable | Used for functional assays; not endogenous |
| DRG neurons (primary) | Not applicable | High endogenous expression in non-peptidergic neurons |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No common variants reported | SNV | Not established | No pathogenic variants in ClinVar; rare variants in population databases (e.g., gnomAD) but no clinical significance. |
Mutation functional classification
Loss of Function (LOF)
No documented loss-of-function mutations in human disease; knockout mice show altered itch/pain behavior.
Gain of Function (GOF)
No documented gain-of-function mutations; constitutive activity may occur in vitro but not clinically relevant.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • signal transduction |
| • G protein-coupled receptor signaling pathway | • plasma membrane |
| • response to beta-alanine | • sensory perception of pain |
| • sensory perception of itch |
Pathways
• GPCR downstream signaling (e.g.
• Gq/11-mediated calcium mobilization)
• Sensory neuron differentiation and function
Protein Summary
MRGPRD is a 7-transmembrane GPCR of the Mas-related gene family. It is selectively expressed in a subset of DRG neurons that are involved in nociception and pruriception. Activation by beta-alanine leads to intracellular calcium increase via Gq/11 proteins. MRGPRD is essential for the proper wiring of sensory neurons and has been shown to mediate histamine-independent itch. Its restricted expression pattern makes it an attractive target for peripheral analgesics.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MRGPRD Knockout HEK293 Cell Line | EDJ-KQ7574 | Human | 116512 | Details Get a Quote |
| MRGPRD Knockout HeLa Cell Line | EDJ-KQ57993 | Human | 116512 | Details Get a Quote |
| MRGPRD Knockout A-549 Cell Line | EDJ-KQ66479 | Human | 116512 | Details Get a Quote |
| MRGPRD Knockout HCT 116 Cell Line | EDJ-KQ74902 | Human | 116512 | Details Get a Quote |
