MORF4L2 Gene - Mortality Factor 4 Like 2
A chromatin-associated protein involved in transcriptional regulation and DNA repair
Gene Information Card
| Symbol | MORF4L2 |
|---|---|
| Full Name | Mortality Factor 4 Like 2 |
| Gene Type | Protein coding |
| Chromosomal Location | Xq22.2 |
| NCBI Gene ID | 9643 ncbi.nlm.nih.gov/gene/9643 |
| Ensembl ID | ENSG00000123562 |
| UniProt ID | Q15014 |
| OMIM ID | 300774 |
| HGNC ID | 24842 |
| Aliases | MRGX, MORF4L2, KIAA0026 |
Description
MORF4L2 (Mortality Factor 4 Like 2) is a protein-coding gene located on the X chromosome. It encodes a component of the NuA4 histone acetyltransferase complex and the MSIN3A histone deacetylase complex, playing a role in chromatin remodeling, transcriptional regulation, and DNA repair. The protein is ubiquitously expressed and is involved in cell cycle control and senescence.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Altered expression may affect chromatin remodeling and transcriptional regulation, contributing to oncogenesis. | NCBI Gene, COSMIC |
| Intellectual disability (X-linked) | Mutations in MORF4L2 have been associated with X-linked intellectual disability, likely due to disrupted chromatin regulation. | OMIM #300774 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Brain | 10.5 | Medium |
| Lung | 8.3 | Low |
| Liver | 6.1 | Low |
| Heart | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 12.0 | Cervical cancer cell line |
| K562 | 9.8 | Leukemia cell line |
| HEK293 | 8.5 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Likely loss of start codon, reduced protein expression |
| c.487C>T (p.Arg163Trp) | Missense | <0.01% | Associated with intellectual disability; may disrupt protein interactions |
Mutation functional classification
Loss of Function (LOF)
Loss-of-function mutations in MORF4L2 are rare but may impair chromatin remodeling and transcriptional regulation, contributing to developmental disorders.
Gain of Function (GOF)
No gain-of-function mutations have been reported in MORF4L2.
Dominant Negative (DN)
Dominant-negative effects have not been described for MORF4L2 mutations.
View complete mutation data：
Gene Ontology (GO)
| • chromatin organization (GO:0006325) | • transcription (GO:0006351) |
| • nucleus (GO:0005634) | • protein binding (GO:0005515) |
| • DNA repair (GO:0006281) |
Pathways
• NuA4 histone acetyltransferase complex
• MSIN3A histone deacetylase complex
• Chromatin remodeling
Protein Summary
The MORF4L2 protein (also known as MRGX) is a 258-amino acid protein that localizes to the nucleus. It contains a chromodomain-like region and interacts with histone-modifying enzymes. It is a core component of both the NuA4 HAT complex and the MSIN3A HDAC complex, linking it to both activation and repression of gene expression. The protein is involved in cellular senescence, DNA damage response, and cell cycle progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MORF4L2 Knockout HEK293 Cell Line | EDJ-KQ3035 | Human | 9643 | Details Get a Quote |
| MORF4L2 Knockout A-549 Cell Line | EDJ-KQ25643 | Human | 9643 | Details Get a Quote |
| MORF4L2 Knockout HCT 116 Cell Line | EDJ-KQ25644 | Human | 9643 | Details Get a Quote |
| MORF4L2 Knockout HeLa Cell Line | EDJ-KQ25645 | Human | 9643 | Details Get a Quote |
