MOGAT3
Monoacylglycerol O-Acyltransferase 3
Gene Information Card
| Symbol | MOGAT3 |
|---|---|
| Full Name | monoacylglycerol O-acyltransferase 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 7q22.1 |
| NCBI Gene ID | 346606 ncbi.nlm.nih.gov/gene/346606 |
| Ensembl ID | ENSG00000106384 |
| UniProt ID | Q86VF5 |
| OMIM ID | 611938 |
| HGNC ID | 23252 |
| Aliases | DGAT2L7, DC4, MGC46136 |
Description
MOGAT3 encodes monoacylglycerol O-acyltransferase 3, an enzyme that catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. This reaction is a key step in the monoacylglycerol pathway for triacylglycerol synthesis, primarily in the intestine. The protein is localized to the endoplasmic reticulum and is involved in dietary fat absorption.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Obesity | Altered MOGAT3 expression may affect triacylglycerol storage and energy balance. | Limited evidence; inferred from functional role in lipid metabolism. |
| Hypertriglyceridemia | Potential contribution to elevated serum triglycerides via increased intestinal fat absorption. | No direct clinical association reported; based on pathway involvement. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Small intestine | 12.5 | Medium |
| Colon | 3.2 | Low |
| Liver | 0.8 | Not detected |
| Adipose tissue | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Caco-2 | 8.1 | Intestinal epithelial cell line |
| HepG2 | 0.3 | Hepatocellular carcinoma cell line |
| HT-29 | 5.6 | Colorectal adenocarcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown functional effect |
| c.100C>T | synonymous | <0.01% | No predicted effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • 1-acylglycerol-3-phosphate O-acyltransferase activity (GO:0003841) | • endoplasmic reticulum (GO:0005783) |
| • integral component of membrane (GO:0016021) | • fatty acid metabolic process (GO:0006631) |
| • triglyceride biosynthetic process (GO:0019432) |
Pathways
• REACTOME: Triglyceride biosynthesis (R-HSA-75109)
• KEGG: Glycerolipid metabolism (hsa00561)
Protein Summary
MOGAT3 is a 345-amino acid integral membrane protein of the endoplasmic reticulum. It belongs to the diacylglycerol acyltransferase 2 (DGAT2) family and catalyzes the acylation of 2-monoacylglycerol to form diacylglycerol, a precursor for triacylglycerol synthesis. The enzyme is highly expressed in the small intestine and plays a critical role in dietary fat absorption.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MOGAT3 Knockout HEK293 Cell Line | EDJ-KQ14283 | Human | 346606 | Details Get a Quote |
| MOGAT3 Knockout HeLa Cell Line | EDJ-KQ59803 | Human | 346606 | Details Get a Quote |
| MOGAT3 Knockout A-549 Cell Line | EDJ-KQ68271 | Human | 346606 | Details Get a Quote |
| MOGAT3 Knockout HCT 116 Cell Line | EDJ-KQ76646 | Human | 346606 | Details Get a Quote |
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