MOGAT2
Monoacylglycerol O-Acyltransferase 2
Gene Information Card
| Symbol | MOGAT2 |
|---|---|
| Full Name | Monoacylglycerol O-Acyltransferase 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 11q13.5 |
| NCBI Gene ID | 80168 ncbi.nlm.nih.gov/gene/80168 |
| Ensembl ID | ENSG00000149257 |
| UniProt ID | Q3SYC2 |
| OMIM ID | 610397 |
| HGNC ID | 23255 |
| Aliases | MGAT2, MOGAT2, DC2, hMGAT2 |
Description
MOGAT2 encodes monoacylglycerol O-acyltransferase 2, an integral membrane protein that catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. This enzyme plays a key role in the re-esterification of dietary fat in enterocytes, contributing to triacylglycerol formation and chylomicron assembly. MOGAT2 is predominantly expressed in the small intestine and is involved in lipid absorption and energy homeostasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Obesity | Altered MOGAT2 expression may affect dietary fat absorption and energy balance, contributing to obesity risk. | Association studies (PMID: 21518876) |
| Hypertriglyceridemia | Increased MOGAT2 activity may enhance triacylglycerol synthesis, leading to elevated plasma triglycerides. | Functional studies in animal models (PMID: 19033660) |
| Non-alcoholic fatty liver disease (NAFLD) | MOGAT2-mediated lipid flux from intestine to liver may influence hepatic steatosis. | Expression analysis (PMID: 23943769) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Small intestine | 45.2 | High |
| Colon | 12.8 | Medium |
| Stomach | 6.5 | Low |
| Liver | 1.2 | Not detected |
| Adipose tissue | 0.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Caco-2 | 38.5 | Intestinal epithelial cell line; high expression |
| HT-29 | 22.1 | Colorectal adenocarcinoma cell line; moderate expression |
| HepG2 | 0.9 | Hepatocellular carcinoma cell line; very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.419C>T (p.Pro140Leu) | Missense | 0.01% (gnomAD) | Unknown functional impact; rare variant |
| c.758G>A (p.Arg253His) | Missense | 0.005% (gnomAD) | Predicted benign by in silico tools |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in MOGAT2.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • 2-acylglycerol O-acyltransferase activity (GO:0003841) | • fatty acid metabolic process (GO:0006631) |
| • integral component of membrane (GO:0016021) | • triacylglycerol biosynthetic process (GO:0019432) |
| • cellular lipid metabolic process (GO:0044255) |
Pathways
• Triacylglycerol synthesis (Reactome: R-HSA-75105)
• Fat digestion and absorption (KEGG: hsa04975)
Protein Summary
Monoacylglycerol O-acyltransferase 2 (MOGAT2) is a 334-amino acid integral membrane protein localized to the endoplasmic reticulum. It catalyzes the conversion of 2-monoacylglycerol and fatty acyl-CoA to diacylglycerol, a key step in the monoacylglycerol pathway of triacylglycerol synthesis. The enzyme is highly expressed in the small intestine and is essential for efficient dietary fat absorption. MOGAT2 belongs to the MBOAT (membrane-bound O-acyltransferase) family and shares sequence similarity with other MGAT and DGAT enzymes.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MOGAT2 Knockout HEK293 Cell Line | EDJ-KQ2657 | Human | 80168 | Details Get a Quote |
| MOGAT2 Knockout HeLa Cell Line | EDJ-KQ57303 | Human | 80168 | Details Get a Quote |
| MOGAT2 Knockout A-549 Cell Line | EDJ-KQ65811 | Human | 80168 | Details Get a Quote |
| MOGAT2 Knockout HCT 116 Cell Line | EDJ-KQ74234 | Human | 80168 | Details Get a Quote |
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