MMP16 Gene - Matrix Metallopeptidase 16
Membrane-type matrix metalloproteinase involved in extracellular matrix remodeling and cancer progression
Gene Information Card
| Symbol | MMP16 |
|---|---|
| Full Name | Matrix Metallopeptidase 16 |
| Gene Type | protein-coding |
| Chromosomal Location | 8q21.3 |
| NCBI Gene ID | 4325 ncbi.nlm.nih.gov/gene/4325 |
| Ensembl ID | ENSG00000156136 |
| UniProt ID | P51512 |
| OMIM ID | 602262 |
| HGNC ID | 7162 |
| Aliases | MT3-MMP, MTMMP3, MMP-X2 |
Description
MMP16 (Matrix Metallopeptidase 16) encodes a member of the matrix metalloproteinase (MMP) family, specifically a membrane-type MMP (MT3-MMP). This protein is anchored to the cell membrane and functions in the degradation of extracellular matrix components, including collagen, gelatin, and fibronectin. It also activates other MMPs, such as pro-MMP2, and plays roles in cell migration, angiogenesis, and tissue remodeling. Dysregulation of MMP16 is implicated in cancer invasion, metastasis, and inflammatory diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Glioma | MMP16 overexpression promotes tumor invasion and angiogenesis via ECM degradation and MMP2 activation. | PMID: 19029987 |
| Breast Cancer | Elevated MMP16 expression correlates with poor prognosis and metastasis through enhanced cell migration. | PMID: 22926525 |
| Osteoarthritis | MMP16 contributes to cartilage degradation by cleaving aggrecan and type II collagen. | PMID: 17186463 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.3 | Medium |
| Lung | 8.7 | Low |
| Breast | 6.5 | Low |
| Colon | 4.2 | Low |
| Ovary | 9.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| U-87 MG (glioma) | 15.2 | High expression |
| MCF7 (breast cancer) | 7.8 | Moderate expression |
| A549 (lung cancer) | 5.3 | Low expression |
| HEK 293 (embryonic kidney) | 3.1 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234G>A (p.Gly412Arg) | Missense | <0.01% | Unknown functional impact |
| c.789_790insC | Frameshift | <0.01% | Predicted loss of function |
| c.1567C>T (p.Arg523Trp) | Missense | <0.01% | Reported in COSMIC for colorectal cancer |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.789_790insC) likely result in truncated, non-functional protein.
Gain of Function (GOF)
Not well documented; some missense variants may alter substrate specificity but evidence is limited.
Dominant Negative (DN)
No known dominant-negative mutations reported for MMP16.
View complete mutation data：
Gene Ontology (GO)
| • metalloendopeptidase activity | • extracellular matrix disassembly |
| • collagen catabolic process | • proteolysis |
| • cell migration | • angiogenesis |
| • membrane |
Pathways
• Matrix Metalloproteinases
• Extracellular matrix organization
• Degradation of the extracellular matrix
• Activation of MMP2 by MMP16
Protein Summary
MMP16 (MT3-MMP) is a 607-amino acid transmembrane protein with a catalytic domain, hemopexin-like domain, and a cytoplasmic tail. It is synthesized as a zymogen and activated by furin cleavage. The protein localizes to the cell surface and pericellular space, where it degrades ECM components and activates pro-MMP2. Its expression is tightly regulated in normal tissues but frequently upregulated in cancers, contributing to invasive behavior.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MMP16 Knockout HEK293 Cell Line | EDJ-KQ5223 | Human | 4325 | Details Get a Quote |
| MMP16 Knockout HeLa Cell Line | EDJ-KQ53889 | Human | 4325 | Details Get a Quote |
| MMP16 Knockout A-549 Cell Line | EDJ-KQ62381 | Human | 4325 | Details Get a Quote |
| MMP16 Knockout HCT 116 Cell Line | EDJ-KQ70850 | Human | 4325 | Details Get a Quote |
| MMP16 Knockout HAP1 Cell Line | EDC09378 | Human | 4325 | Details Get a Quote |
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