MIDN Gene - Midnolin
Comprehensive gene card for MIDN (midnolin), including genomic information, expression, and disease associations.
Gene Information Card
| Symbol | MIDN |
|---|---|
| Full Name | midnolin |
| Gene Type | protein-coding |
| Chromosomal Location | 19p13.3 |
| NCBI Gene ID | 90007 ncbi.nlm.nih.gov/gene/90007 |
| Ensembl ID | ENSG00000167552 |
| UniProt ID | Q9NPA0 |
| OMIM ID | 609391 |
| HGNC ID | 25996 |
| Aliases | FLJ20032, MGC138499 |
Description
MIDN (midnolin) is a protein-coding gene located on chromosome 19p13.3. It encodes a nuclear protein that may function as a transcription factor involved in neuronal development and differentiation. The protein contains a midnolin domain and is expressed in various tissues, with highest levels in the brain.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not established | No direct evidence from ClinVar, OMIM, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Testis | 8.2 | Low |
| Lung | 5.1 | Low |
| Liver | 3.0 | Not detected |
| Heart | 2.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y | 10.0 | Neuronal cell line |
| HeLa | 6.5 | Cervical cancer |
| HEK293 | 4.2 | Embryonic kidney |
| K562 | 3.1 | Leukemia |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown |
| c.100C>T | synonymous | <0.01% | No effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • nucleus | • DNA binding |
| • transcription regulation | • protein binding |
Pathways
• No specific pathways annotated
Protein Summary
Midnolin is a 45 kDa nuclear protein containing a conserved midnolin domain. It is predicted to act as a transcription factor, potentially regulating genes involved in neuronal differentiation and development. Its exact molecular function remains under investigation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MIDN Knockout HEK293 Cell Line | EDJ-KQ10546 | Human | 90007 | Details Get a Quote |
| MIDN Knockout A-549 Cell Line | EDC07768 | Human | 90007 | Details Get a Quote |
| MIDN Knockout HCT 116 Cell Line | EDJ-KQ37991 | Human | 90007 | Details Get a Quote |
| MIDN Knockout HeLa Cell Line | EDJ-KQ36688 | Human | 90007 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
