MIDEAS Gene - Mitotic Deacetylase Associated SANT Domain Protein
Comprehensive genomic and functional overview of MIDEAS, a chromatin-associated protein involved in transcriptional regulation and cell cycle control.
Gene Information Card
| Symbol | MIDEAS |
|---|---|
| Full Name | mitotic deacetylase associated SANT domain protein |
| Gene Type | protein-coding |
| Chromosomal Location | 14q24.3 |
| NCBI Gene ID | 115416 ncbi.nlm.nih.gov/gene/115416 |
| Ensembl ID | ENSG00000100823 |
| UniProt ID | Q8N5K1 |
| OMIM ID | 617598 |
| HGNC ID | HGNC:28235 |
| Aliases | FLJ12787, MIDEAS, MIDEAS1 |
Description
MIDEAS (mitotic deacetylase associated SANT domain protein) encodes a protein that contains a SANT domain, which is a DNA-binding domain often found in chromatin-remodeling complexes. The protein is involved in transcriptional regulation and may play a role in cell cycle progression, particularly during mitosis. It is associated with the deacetylase complex and influences chromatin structure and gene expression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not established | No direct evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.3 | Low |
| Lung | 6.1 | Low |
| Liver | 4.7 | Low |
| Kidney | 5.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.2 | Embryonic kidney cells |
| HeLa | 8.9 | Cervical cancer cells |
| K562 | 7.5 | Leukemia cells |
| A549 | 6.8 | Lung cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1010C>T (p.Thr337Met) | missense | Rare | Unknown functional effect |
| c.1456G>A (p.Glu486Lys) | missense | Rare | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in COSMIC or ClinVar.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • nucleus (GO:0005634) |
| • DNA binding (GO:0003677) | • regulation of transcription (GO:0006355) |
| • chromatin organization (GO:0006325) |
Pathways
• Chromatin organization
• Transcriptional regulation by chromatin remodeling
Protein Summary
The MIDEAS protein (UniProt Q8N5K1) contains a SANT domain that mediates DNA binding and interaction with chromatin-modifying complexes. It is localized to the nucleus and is implicated in the regulation of transcription and chromatin structure. The protein is expressed in multiple tissues, with highest levels in testis. Its precise biological functions and disease associations remain under investigation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MIDEAS Knockout HEK293 Cell Line | EDJ-KQ10059 | Human | 91748 | Details Get a Quote |
| MIDEAS Knockout A-549 Cell Line | EDJ-KQ38392 | Human | 91748 | Details Get a Quote |
| MIDEAS Knockout HCT 116 Cell Line | EDJ-KQ38394 | Human | 91748 | Details Get a Quote |
| MIDEAS Knockout HeLa Cell Line | EDJ-KQ38395 | Human | 91748 | Details Get a Quote |
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