METTL6: Methyltransferase Like 6
A tRNA methyltransferase involved in protein synthesis and implicated in cancer
Gene Information Card
| Symbol | METTL6 |
|---|---|
| Full Name | Methyltransferase Like 6 |
| Gene Type | Protein coding |
| Chromosomal Location | 3p14.1 |
| NCBI Gene ID | 131965 ncbi.nlm.nih.gov/gene/131965 |
| Ensembl ID | ENSG00000163827 |
| UniProt ID | Q8TCB7 |
| OMIM ID | 618903 |
| HGNC ID | 26779 |
| Aliases | MGC10744, METTL6A |
Description
METTL6 (Methyltransferase Like 6) is a protein-coding gene that encodes a methyltransferase enzyme responsible for the N3-methylcytidine (m3C) modification of tRNA. This modification is critical for tRNA stability and efficient protein synthesis. METTL6 is part of a complex that includes METTL2 and METTL8, and its activity is essential for cellular proliferation. Dysregulation of METTL6 has been linked to various cancers, including hepatocellular carcinoma and breast cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | Overexpression of METTL6 promotes cell proliferation and tumor growth via enhanced tRNA methylation and translation of oncogenic proteins. | PMID: 31932796 |
| Breast cancer | METTL6 is upregulated and associated with poor prognosis; its knockdown reduces cell viability and invasion. | PMID: 32697912 |
| Colorectal cancer | METTL6 expression is elevated and correlates with tumor stage and metastasis. | PMID: 33357406 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Breast | 8.3 | Medium |
| Colon | 10.1 | Medium |
| Lung | 6.7 | Low |
| Kidney | 7.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.2 | Hepatocellular carcinoma cell line |
| MCF7 | 11.4 | Breast cancer cell line |
| HT-29 | 9.8 | Colorectal cancer cell line |
| A549 | 5.6 | Lung cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.374C>T (p.Thr125Met) | Missense | 0.01% | Unknown; predicted benign |
| c.482G>A (p.Arg161Gln) | Missense | 0.005% | Unknown; predicted possibly damaging |
| c.631_632insA | Frameshift | <0.001% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.631_632insA) are predicted to cause loss of function by truncating the protein.
Gain of Function (GOF)
No gain-of-function mutations have been reported.
Dominant Negative (DN)
No dominant-negative mutations have been described.
View complete mutation data：
Gene Ontology (GO)
| • tRNA methyltransferase activity | • methylation |
| • tRNA processing | • cytoplasm |
| • nucleus |
Pathways
• tRNA modification in the nucleus and cytoplasm
• Protein synthesis
Protein Summary
METTL6 is a 288-amino acid protein that functions as a tRNA methyltransferase, specifically catalyzing the formation of N3-methylcytidine (m3C) at position 32 of tRNA. It localizes to both the cytoplasm and nucleus and interacts with other methyltransferases (METTL2, METTL8) to modify tRNA substrates. The protein contains a conserved methyltransferase domain and is essential for maintaining tRNA stability and translation efficiency. Overexpression in cancer cells promotes proliferation and tumorigenesis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| METTL6 Knockout HEK293 Cell Line | EDJ-KQ9279 | Human | 131965 | Details Get a Quote |
| METTL6 Knockout HCT 116 Cell Line | EDJ-KQ34645 | Human | 131965 | Details Get a Quote |
| METTL6 Knockout A-549 Cell Line | EDJ-KQ35888 | Human | 131965 | Details Get a Quote |
| METTL6 Knockout HeLa Cell Line | EDJ-KQ35890 | Human | 131965 | Details Get a Quote |
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