METTL25B Gene - Methyltransferase Like 25B
Genetic and functional insights into METTL25B, a putative RNA methyltransferase, with relevance to cancer and cellular regulation.
Gene Information Card
| Symbol | METTL25B |
|---|---|
| Full Name | Methyltransferase Like 25B |
| Gene Type | Protein coding |
| Chromosomal Location | Chr 1q32.1 (GRCh38) |
| NCBI Gene ID | 124491 ncbi.nlm.nih.gov/gene/124491 |
| Ensembl ID | ENSG00000143178 |
| UniProt ID | Q5T8I9 |
| OMIM ID | Not available |
| HGNC ID | HGNC:26425 |
| Aliases | FLJ46365, MGC163417 |
Description
METTL25B is a protein-coding gene that encodes a putative methyltransferase enzyme. It belongs to the methyltransferase-like family, which is involved in various cellular processes including RNA modification, gene regulation, and metabolism. The protein contains a conserved methyltransferase domain, suggesting a role in transferring methyl groups to substrates such as nucleic acids or proteins. METTL25B is expressed in multiple tissues and has been implicated in cancer biology, though its precise functions are still under investigation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered expression and potential methylation of RNA targets may affect oncogenic pathways. | Expression data from COSMIC and literature suggest dysregulation in tumors. |
| Neurodevelopmental disorders | Potential role in neural development via RNA methylation; limited evidence. | In silico predictions and expression in brain tissues. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Brain | 8.5 | Low |
| Liver | 6.2 | Low |
| Kidney | 5.1 | Low |
| Lung | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.2 | High expression |
| A549 | 10.1 | Moderate |
| MCF7 | 8.7 | Moderate |
| K562 | 6.3 | Low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123A>G (p.Ile41Met) | Missense | 0.01% (gnomAD) | Unknown; predicted benign |
| c.456C>T (p.Ser152Leu) | Missense | 0.005% | Potential impact on protein stability |
| c.789_790insA (frameshift) | Insertion | Rare | Loss of function likely |
Mutation functional classification
Loss of Function (LOF)
Frameshift and truncating mutations likely lead to loss of methyltransferase activity, potentially affecting RNA modification and gene expression.
Gain of Function (GOF)
No evidence for gain-of-function mutations; overexpression may contribute to oncogenesis in some contexts.
Dominant Negative (DN)
No evidence for dominant-negative effects; mutations are mostly recessive or haploinsufficient.
View complete mutation data：
Gene Ontology (GO)
| • methyltransferase activity | • RNA binding |
| • nucleus | • cytoplasm |
| • regulation of gene expression |
Pathways
• RNA methylation
• Gene expression regulation
Protein Summary
The METTL25B protein is a putative methyltransferase that likely catalyzes the transfer of methyl groups to RNA or protein substrates. It contains a conserved methyltransferase domain and is localized to both nucleus and cytoplasm. Its expression varies across tissues, with highest levels in testis and brain. The protein may play a role in RNA processing and gene regulation, and its dysregulation has been linked to cancer. Further studies are needed to fully elucidate its substrates and biological functions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| METTL25B Knockout HEK293 Cell Line | EDJ-KQ14245 | Human | 51093 | Details Get a Quote |
| METTL25B Knockout HCT 116 Cell Line | EDJ-KQ43024 | Human | 51093 | Details Get a Quote |
| METTL25B Knockout A-549 Cell Line | EDJ-KQ44238 | Human | 51093 | Details Get a Quote |
| METTL25B Knockout HeLa Cell Line | EDJ-KQ44240 | Human | 51093 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
