METTL21A: Methyltransferase 21A, HSPA8 Lysine Methyltransferase
A comprehensive biomedical overview of METTL21A, including gene structure, expression, disease associations, mutations, and functional classification.
Gene Information Card
| Symbol | METTL21A |
|---|---|
| Full Name | Methyltransferase 21A, HSPA8 Lysine Methyltransferase |
| Gene Type | Protein coding |
| Chromosomal Location | 1q41 |
| NCBI Gene ID | 151194 ncbi.nlm.nih.gov/gene/151194 |
| Ensembl ID | ENSG00000143156 |
| UniProt ID | Q8WXB1 |
| OMIM ID | 617062 |
| HGNC ID | 25181 |
| Aliases | Methyltransferase-like 21A, FLJ23445, HSPA8-specific methyltransferase |
Description
METTL21A encodes a protein lysine methyltransferase that specifically methylates HSPA8 (heat shock 70 kDa protein 8) at lysine 561. This modification is implicated in regulating HSPA8's chaperone activity and cellular stress response. The gene is located on chromosome 1q41 and is expressed in various tissues, with highest levels in the brain and testis. METTL21A belongs to the methyltransferase superfamily and is involved in protein methylation processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer | Altered expression may affect HSPA8-mediated protein folding and stress response, potentially influencing tumor progression. | Limited direct evidence; inferred from HSPA8's role in cancer. |
| Neurodegenerative disorders | Methylation of HSPA8 could impact protein quality control, relevant to neurodegeneration. | Hypothetical; no direct clinical association reported. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.3 | Medium |
| Testis | 10.1 | Medium |
| Liver | 5.2 | Low |
| Kidney | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 8.5 | Moderate expression |
| HEK293 | 7.2 | Moderate expression |
| A549 | 6.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | 0.001% (gnomAD) | Potential loss of methyltransferase activity; not clinically validated. |
| c.200A>G (p.Asp67Gly) | Missense | 0.002% (gnomAD) | Unknown effect; predicted benign by in silico tools. |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No evidence of gain-of-function mutations.
Dominant Negative (DN)
Not described.
View complete mutation data：
Gene Ontology (GO)
| • Methyltransferase activity | • Protein methyltransferase activity |
| • Lysine N-methyltransferase activity | • Cytoplasm |
| • Nucleus |
Pathways
• Protein methylation
• Cellular response to stress
Protein Summary
METTL21A is a 223-amino acid protein that belongs to the class I methyltransferase family. It catalyzes the transfer of a methyl group from S-adenosylmethionine to the epsilon-amino group of lysine 561 on HSPA8. This methylation is thought to modulate HSPA8's ATPase activity and its interaction with co-chaperones, thereby influencing protein folding and stress response. The protein is predominantly cytoplasmic but may also localize to the nucleus. Its expression is highest in brain and testis, suggesting a role in neuronal and reproductive functions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| METTL21A Knockout HEK293 Cell Line | EDJ-KQ10637 | Human | 151194 | Details Get a Quote |
| METTL21A Knockout A-549 Cell Line | EDJ-KQ39466 | Human | 151194 | Details Get a Quote |
| METTL21A Knockout HCT 116 Cell Line | EDJ-KQ39468 | Human | 151194 | Details Get a Quote |
| METTL21A Knockout HeLa Cell Line | EDJ-KQ39469 | Human | 151194 | Details Get a Quote |
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