MARCO
Macrophage Receptor with Collagenous Structure
Gene Information Card
| Symbol | MARCO |
|---|---|
| Full Name | Macrophage Receptor with Collagenous Structure |
| Gene Type | protein-coding |
| Chromosomal Location | 2q14.2 |
| NCBI Gene ID | 8685 ncbi.nlm.nih.gov/gene/8685 |
| Ensembl ID | ENSG00000019169 |
| UniProt ID | Q9UEW3 |
| OMIM ID | 604653 |
| HGNC ID | 6895 |
| Aliases | SCARA2, SR-A6 |
Description
MARCO (Macrophage Receptor with Collagenous Structure) encodes a class A scavenger receptor primarily expressed on macrophages. The protein mediates binding and phagocytosis of bacteria, apoptotic cells, and environmental particles, playing a key role in innate immunity and tissue homeostasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Atherosclerosis | MARCO mediates uptake of oxidized LDL by macrophages, contributing to foam cell formation | PMID: 11567032 |
| Tuberculosis | MARCO binds Mycobacterium tuberculosis, facilitating phagocytosis and clearance | PMID: 16920926 |
| Influenza | MARCO recognizes influenza A virus, promoting viral clearance by alveolar macrophages | PMID: 23543757 |
| Sepsis | MARKO knockout mice show increased susceptibility to bacterial sepsis due to impaired bacterial clearance | PMID: 10415057 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Spleen | 8.3 | Medium |
| Liver | 5.1 | Low |
| Lymph node | 4.7 | Low |
| Bone marrow | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 0.2 | Low baseline; upregulated upon differentiation to macrophages |
| U937 (monocyte) | 0.1 | Low baseline; induced by PMA |
| HepG2 (hepatocyte) | 0.0 | Not expressed |
| A549 (lung epithelial) | 0.0 | Not expressed |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.124C>T (p.Arg42Cys) | Missense | <0.01% | Reduced ligand binding affinity |
| c.487G>A (p.Gly163Ser) | Missense | <0.01% | Altered collagenous domain stability |
| c.1022_1023del (p.Leu341fs) | Frameshift | <0.01% | Loss of function; truncated protein |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense variants that truncate the protein or disrupt the collagenous domain impair receptor function and bacterial clearance.
Gain of Function (GOF)
No gain-of-function mutations have been reported for MARCO.
Dominant Negative (DN)
No dominant-negative mutations have been described for MARCO.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Scavenger receptors in atherosclerosis (KEGG hsa05417)
• Phagosome (KEGG hsa04145)
• Tuberculosis (KEGG hsa05152)
Protein Summary
MARCO is a 520-amino acid transmembrane scavenger receptor with a short N-terminal cytoplasmic domain, a transmembrane region, and a large extracellular domain containing a collagenous region. It forms a trimeric structure that binds a broad range of ligands, including bacteria, oxidized LDL, and environmental particles. The protein is predominantly expressed on macrophages, especially alveolar macrophages, and is critical for pathogen clearance and inflammatory regulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MARCO Knockout HEK293 Cell Line | EDJ-KQ6325 | Human | 8685 | Details Get a Quote |
| MARCOL Knockout HEK293 Cell Line | EDJ-KQ14204 | Human | 105378220 | Details Get a Quote |
| MARCOL Knockout HeLa Cell Line | EDJ-KQ44154 | Human | 105378220 | Details Get a Quote |
| MARCO Knockout HeLa Cell Line | EDJ-KQ54978 | Human | 8685 | Details Get a Quote |
| MARCO Knockout A-549 Cell Line | EDJ-KQ63460 | Human | 8685 | Details Get a Quote |
| MARCO Knockout HCT 116 Cell Line | EDJ-KQ71928 | Human | 8685 | Details Get a Quote |
Displaying Records 1 To 6 Of 6 Records
