MAP1S: Microtubule-Associated Protein 1S
A key regulator of autophagy, mitophagy, and genome stability, implicated in cancer and neurodegenerative disorders.
Gene Information Card
| Symbol | MAP1S |
|---|---|
| Full Name | Microtubule-Associated Protein 1S |
| Gene Type | Protein coding |
| Chromosomal Location | 19p13.11 |
| NCBI Gene ID | 55201 ncbi.nlm.nih.gov/gene/55201 |
| Ensembl ID | ENSG00000167286 |
| UniProt ID | Q66K74 |
| OMIM ID | 609267 |
| HGNC ID | 15719 |
| Aliases | MAP1A/1B light chain 3 related protein, MAP1S_HUMAN, C19orf5, MAP1A/1BLC3, MTAP1S |
Description
MAP1S (Microtubule-Associated Protein 1S) encodes a protein that belongs to the microtubule-associated protein 1 family. It functions as a scaffold linking microtubules to autophagic machinery, facilitating autophagy and mitophagy. MAP1S also plays a role in maintaining genome stability by promoting DNA repair and regulating the mitotic spindle. Its dysregulation is linked to various cancers and neurodegenerative diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | MAP1S loss impairs autophagy, leading to accumulation of damaged organelles and genomic instability, promoting tumorigenesis. | PMID: 21804562 |
| Prostate cancer | Reduced MAP1S expression correlates with poor prognosis; loss of MAP1S enhances cell proliferation and invasion via defective mitophagy. | PMID: 23376921 |
| Alzheimer's disease | MAP1S deficiency impairs clearance of tau aggregates and damaged mitochondria, contributing to neuronal cell death. | PMID: 24908484 |
| Parkinson's disease | MAP1S-mediated mitophagy is critical for removing dysfunctional mitochondria; loss of MAP1S exacerbates dopaminergic neuron loss. | PMID: 26912668 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Brain | 8.3 | Low |
| Heart | 6.1 | Low |
| Kidney | 9.7 | Low |
| Testis | 15.2 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 (liver cancer) | 14.8 | High expression |
| SH-SY5Y (neuroblastoma) | 7.2 | Moderate expression |
| HeLa (cervical cancer) | 10.1 | Moderate expression |
| MCF7 (breast cancer) | 5.6 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.487C>T (p.Arg163*) | Nonsense | <0.1% | Loss of function; truncation of protein, likely impairing autophagy |
| c.632A>G (p.Glu211Gly) | Missense | <0.1% | Unknown; predicted to affect protein stability |
| c.1015_1016insA (p.Thr339Asnfs*12) | Frameshift | <0.1% | Loss of function; premature stop codon |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations (e.g., p.Arg163*, p.Thr339Asnfs*12) lead to truncated or unstable protein, impairing autophagy and mitophagy.
Gain of Function (GOF)
No gain-of-function mutations reported in MAP1S.
Dominant Negative (DN)
No dominant-negative mutations reported in MAP1S.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Autophagy - Homo sapiens (human) (KEGG: hsa04140)
• Mitophagy - animal (Reactome: R-HSA-5205647)
• Cellular responses to stress (Reactome: R-HSA-2262752)
Protein Summary
The MAP1S protein (UniProt Q66K74) is a 1,099-amino-acid microtubule-associated protein that contains an N-terminal microtubule-binding domain and a C-terminal region that interacts with LC3/GABARAP family proteins. It acts as a molecular linker between microtubules and the autophagic machinery, promoting autophagosome formation and maturation. MAP1S also localizes to the mitotic spindle and centrosomes, where it contributes to chromosome segregation and genomic stability. Post-translational modifications include phosphorylation and ubiquitination, which regulate its stability and function.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAP1S Knockout HEK293 Cell Line | EDJ-KQ14193 | Human | 55201 | Details Get a Quote |
| MAP1S Knockout A-549 Cell Line | EDJ-KQ44135 | Human | 55201 | Details Get a Quote |
| MAP1S Knockout HCT 116 Cell Line | EDJ-KQ44136 | Human | 55201 | Details Get a Quote |
| MAP1S Knockout HeLa Cell Line | EDJ-KQ44137 | Human | 55201 | Details Get a Quote |
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