MAP1LC3B2 Gene - Microtubule Associated Protein 1 Light Chain 3 Beta 2
Essential autophagy-related gene with roles in cellular homeostasis and disease
Gene Information Card
| Symbol | MAP1LC3B2 |
|---|---|
| Full Name | Microtubule Associated Protein 1 Light Chain 3 Beta 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 12q24.22 |
| NCBI Gene ID | 643246 ncbi.nlm.nih.gov/gene/643246 |
| Ensembl ID | ENSG00000178971 |
| UniProt ID | Q9GZQ8 |
| OMIM ID | 609604 |
| HGNC ID | 29800 |
| Aliases | LC3B2, ATG8F, MAP1LC3B, LC3B |
Description
MAP1LC3B2 (Microtubule Associated Protein 1 Light Chain 3 Beta 2) is a protein-coding gene that encodes a member of the ATG8 family of ubiquitin-like proteins. This protein is essential for autophagy, a cellular degradation process that removes damaged organelles and proteins. MAP1LC3B2 is conjugated to phosphatidylethanolamine and localizes to autophagosomal membranes, serving as a key marker for autophagic activity. It is involved in cargo recognition and autophagosome formation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Dysregulation of autophagy; altered LC3B2 expression affects tumor suppression or progression | PMID: 25643397 |
| Neurodegenerative disorders (e.g., Alzheimer's disease) | Impaired autophagy leads to accumulation of toxic protein aggregates | PMID: 22966423 |
| Inflammatory bowel disease | Autophagy defects in intestinal epithelium; MAP1LC3B2 variants associated with Crohn's disease | PMID: 21102463 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 10.2 | Medium |
| Liver | 8.9 | Low |
| Kidney | 11.3 | Medium |
| Lung | 9.7 | Low |
| Skeletal muscle | 7.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.3 | High expression |
| HEK293 | 13.8 | High expression |
| SH-SY5Y | 11.2 | Medium expression |
| MCF7 | 9.5 | Low expression |
| HepG2 | 10.1 | Medium expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Loss of start codon; likely loss of function |
| c.214C>T (p.Arg72Trp) | Missense | <0.01% | Unknown functional effect |
| c.361G>A (p.Gly121Ser) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
Loss-of-function mutations in MAP1LC3B2 are rare and may impair autophagy, potentially contributing to cellular stress and disease susceptibility.
Gain of Function (GOF)
No gain-of-function mutations have been reported for MAP1LC3B2.
Dominant Negative (DN)
No dominant-negative mutations have been described for MAP1LC3B2.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Autophagy - animal (KEGG: hsa04140)
• Mitophagy (Reactome: R-HSA-5205647)
• Selective autophagy (Reactome: R-HSA-9663891)
Protein Summary
MAP1LC3B2 is a 125-amino acid protein (14.6 kDa) belonging to the ATG8 family. It contains a ubiquitin-like domain and a C-terminal glycine that is conjugated to phosphatidylethanolamine during autophagy. The protein is essential for autophagosome elongation and cargo recruitment. It is widely expressed and serves as a standard marker for autophagy detection.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAP1LC3B2 Knockout HEK293 Cell Line | EDJ-KQ858 | Human | 643246 | Details Get a Quote |
| MAP1LC3B2 Knockout A-549 Cell Line | EDJ-KQ20992 | Human | 643246 | Details Get a Quote |
| MAP1LC3B2 Knockout HCT 116 Cell Line | EDJ-KQ20994 | Human | 643246 | Details Get a Quote |
| MAP1LC3B2 Knockout HeLa Cell Line | EDJ-KQ20995 | Human | 643246 | Details Get a Quote |
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