MAGEA2B
Melanoma-associated antigen 2B
Gene Information Card
| Symbol | MAGEA2B |
|---|---|
| Full Name | MAGE family member A2B |
| Gene Type | protein-coding |
| Chromosomal Location | Xq28 |
| NCBI Gene ID | 266740 ncbi.nlm.nih.gov/gene/266740 |
| Ensembl ID | ENSG00000221867 |
| UniProt ID | P43365 |
| OMIM ID | 300176 |
| HGNC ID | 23769 |
| Aliases | MAGE2B, MAGE-2B, CT1.2B |
Description
MAGEA2B is a member of the melanoma-associated antigen (MAGE) gene family, which encodes cancer-testis antigens. These proteins are normally expressed only in testis and placenta but are aberrantly activated in various cancers, making them targets for cancer immunotherapy. MAGEA2B is located on chromosome Xq28 and shares high sequence similarity with other MAGE-A genes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Melanoma | Overexpression of MAGEA2B as a cancer-testis antigen; recognized by cytotoxic T lymphocytes | PMID: 7539677 |
| Non-small cell lung cancer | Aberrant expression associated with tumor progression and immune evasion | PMID: 14559841 |
| Breast cancer | MAGEA2B expression correlates with poor prognosis and hormone receptor negativity | PMID: 15604238 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 27.8 | High |
| Placenta | 12.3 | Medium |
| Skin | 0.5 | Not detected |
| Lung | 0.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SK-MEL-28 (melanoma) | 45.6 | High expression |
| A549 (lung carcinoma) | 0.8 | Low expression |
| MCF7 (breast cancer) | 1.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | No functional data |
| c.100C>T | synonymous | <0.1% | No known effect |
Mutation functional classification
Loss of Function (LOF)
No documented loss-of-function mutations in MAGEA2B.
Gain of Function (GOF)
Overexpression in tumors suggests potential gain-of-function role in immune evasion.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • cytoplasm (GO:0005737) |
| • cytosol (GO:0005829) | • nucleus (GO:0005634) |
Pathways
• Not assigned to any canonical pathway in Reactome or KEGG.
Protein Summary
MAGEA2B encodes a protein of 314 amino acids (UniProt P43365) belonging to the MAGE family. It contains a conserved MAGE homology domain (MHD) and is localized in the cytoplasm and nucleus. The protein is involved in protein-protein interactions and may modulate transcriptional regulation. As a cancer-testis antigen, it is a target for cancer vaccines and adoptive T-cell therapy.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAGEA2B Knockout HEK293 Cell Line | EDJ-KQ13384 | Human | 266740 | Details Get a Quote |
| MAGEA2B Knockout HCT 116 Cell Line | EDJ-KQ44104 | Human | 266740 | Details Get a Quote |
| MAGEA2B Knockout HeLa Cell Line | EDJ-KQ59356 | Human | 266740 | Details Get a Quote |
| MAGEA2B Knockout A-549 Cell Line | EDJ-KQ67817 | Human | 266740 | Details Get a Quote |
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