LYZL2
Lysozyme Like 2
Gene Information Card
| Symbol | LYZL2 |
|---|---|
| Full Name | Lysozyme Like 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 10p12.1 |
| NCBI Gene ID | 57125 ncbi.nlm.nih.gov/gene/57125 |
| Ensembl ID | ENSG00000120068 |
| UniProt ID | Q9UGM3 |
| OMIM ID | 616484 |
| HGNC ID | 29622 |
| Aliases | LYS2, LYZL, LYZL2 |
Description
LYZL2 (Lysozyme Like 2) is a protein-coding gene that encodes a member of the lysozyme family. The encoded protein has bacteriolytic activity and is involved in host defense. It is expressed in various tissues, including the respiratory tract and reproductive organs.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Testis | 8.3 | Low |
| Prostate | 6.1 | Low |
| Trachea | 5.4 | Low |
| Salivary gland | 4.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 | 15.0 | Lung carcinoma cell line |
| HepG2 | 2.1 | Hepatocellular carcinoma |
| K562 | 1.0 | Chronic myelogenous leukemia |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic mutations reported | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • lysozyme activity | • defense response to bacterium |
| • extracellular region |
Pathways
• No specific pathways annotated
Protein Summary
The LYZL2 protein is a lysozyme-like enzyme with bacteriolytic activity, contributing to innate immune defense. It is secreted and found in extracellular regions, particularly in mucosal tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LYZL2 Knockout HEK293 Cell Line | EDJ-KQ51939 | Human | 119180 | Details Get a Quote |
| LYZL2 Knockout HeLa Cell Line | EDJ-KQ58037 | Human | 119180 | Details Get a Quote |
| LYZL2 Knockout A-549 Cell Line | EDJ-KQ66524 | Human | 119180 | Details Get a Quote |
| LYZL2 Knockout HCT 116 Cell Line | EDJ-KQ74940 | Human | 119180 | Details Get a Quote |
