LVRN (Laeverin)
Aminopeptidase A and placental development regulator
Gene Information Card
| Symbol | LVRN |
|---|---|
| Full Name | Laeverin |
| Gene Type | protein-coding |
| Chromosomal Location | 5q23.1 |
| NCBI Gene ID | 206338 ncbi.nlm.nih.gov/gene/206338 |
| Ensembl ID | ENSG00000164171 |
| UniProt ID | Q5VY30 |
| OMIM ID | 614159 |
| HGNC ID | 26876 |
| Aliases | APA, AP-A, laeverin |
Description
LVRN encodes laeverin, a type II transmembrane zinc-dependent aminopeptidase A (APA) that cleaves N-terminal aspartate and glutamate residues. It is specifically expressed in the placenta, particularly in extravillous trophoblasts, and is involved in cell migration, invasion, and placental development. Dysregulation is associated with preeclampsia.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Preeclampsia | Altered LVRN expression may impair trophoblast invasion and spiral artery remodeling, contributing to placental ischemia and maternal hypertension. | PMID: 21940940; ClinVar: LVRN variants associated with preeclampsia risk |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Placenta | 12.5 | High |
| Testis | 0.8 | Low |
| Kidney | 0.3 | Not detected |
| Liver | 0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| JEG-3 (choriocarcinoma) | 15.2 | High expression; used as model for trophoblast invasion |
| BeWo (choriocarcinoma) | 10.1 | Moderate expression |
| HEK293 | 0.2 | Low/not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.112G>A (p.Gly38Arg) | Missense | <0.01% | Unknown; predicted benign by SIFT |
| c.1457C>T (p.Thr486Met) | Missense | <0.01% | Unknown; predicted possibly damaging by PolyPhen |
Mutation functional classification
Loss of Function (LOF)
Not established; no confirmed loss-of-function variants reported in ClinVar or COSMIC.
Gain of Function (GOF)
Not established.
Dominant Negative (DN)
Not established.
View complete mutation data：
Gene Ontology (GO)
| • aminopeptidase activity (GO:0004177) | • proteolysis (GO:0006508) |
| • plasma membrane (GO:0005886) | • integral component of membrane (GO:0016021) |
| • peptidase activity (GO:0008233) | • zinc ion binding (GO:0008270) |
| • response to steroid hormone (GO:0048545) | • female pregnancy (GO:0007565) |
| • chromatin remodeling (GO:0006338) |
Pathways
• Aminopeptidase A pathway
• Renin-angiotensin system (alternative)
• Placental development and trophoblast invasion
Protein Summary
Laeverin is a 945-amino acid type II transmembrane protein with a zinc-binding motif (HEXXH) characteristic of M1 family aminopeptidases. It is highly glycosylated and localized to the cell surface of extravillous trophoblasts. The protein cleaves angiotensin II to angiotensin III, modulating local blood pressure and trophoblast migration. Its expression is regulated by hypoxia and steroid hormones.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LVRN Knockout HEK293 Cell Line | EDJ-KQ6502 | Human | 206338 | Details Get a Quote |
| LVRN Knockout HCT 116 Cell Line | EDJ-KQ30643 | Human | 206338 | Details Get a Quote |
| LVRN Knockout HeLa Cell Line | EDJ-KQ59059 | Human | 206338 | Details Get a Quote |
| LVRN Knockout A-549 Cell Line | EDJ-KQ67536 | Human | 206338 | Details Get a Quote |
