LUZP4
Leucine Zipper Protein 4: A Cancer-Testis Antigen with Emerging Roles in Gene Regulation and Tumorigenesis
Gene Information Card
| Symbol | LUZP4 |
|---|---|
| Full Name | Leucine Zipper Protein 4 |
| Gene Type | Protein coding |
| Chromosomal Location | Xq23 |
| NCBI Gene ID | 51203 ncbi.nlm.nih.gov/gene/51203 |
| Ensembl ID | ENSG00000102054 |
| UniProt ID | Q9H9E3 |
| OMIM ID | 300712 |
| HGNC ID | 20486 |
| Aliases | CT-28, HOM-TES-85, LUZP4 |
Description
LUZP4 (Leucine Zipper Protein 4) is a protein-coding gene located on the X chromosome. It encodes a member of the leucine zipper family of transcription factors and is classified as a cancer-testis antigen (CT-28). The protein is normally expressed in testis but is aberrantly activated in various cancers, where it may contribute to tumorigenesis by regulating gene expression and cell proliferation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Melanoma | LUZP4 is expressed as a cancer-testis antigen; may elicit immune response | PMID: 12618910 |
| Lung Cancer | Aberrant expression observed; potential biomarker | PMID: 15625619 |
| Breast Cancer | Overexpression reported; associated with poor prognosis | PMID: 23542377 |
| Ovarian Cancer | Expression detected in tumor tissues; role in immune evasion | PMID: 19139070 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 27.8 | High |
| Lung | 0.2 | Not detected |
| Breast | 0.1 | Not detected |
| Ovary | 0.1 | Not detected |
| Skin | 0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A375 (melanoma) | 15.3 | Cancer cell line with LUZP4 expression |
| NCI-H1299 (lung) | 8.7 | Lung cancer cell line |
| MCF7 (breast) | 6.2 | Breast cancer cell line |
| SK-OV-3 (ovary) | 4.5 | Ovarian cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.1% | Likely benign; no functional data |
| c.100C>T | Nonsense | <0.1% | Predicted loss-of-function; rare |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., c.100C>T) are predicted to cause premature truncation and loss of protein function.
Gain of Function (GOF)
No gain-of-function mutations have been reported.
Dominant Negative (DN)
No dominant-negative mutations have been described.
View complete mutation data：
Gene Ontology (GO)
| • DNA binding | • transcription factor activity |
| • RNA polymerase II-specific | • regulation of transcription |
| • DNA-templated | • nucleus |
Pathways
• Cancer-testis antigen expression in cancer
Protein Summary
LUZP4 is a 451-amino acid protein containing a leucine zipper domain, characteristic of transcription factors. It localizes to the nucleus and is thought to regulate gene expression. As a cancer-testis antigen, its expression is normally restricted to testis but is reactivated in multiple cancer types, making it a potential target for cancer immunotherapy.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LUZP4 Knockout HEK293 Cell Line | EDJ-KQ10978 | Human | 51213 | Details Get a Quote |
| LUZP4 Knockout HeLa Cell Line | EDJ-KQ56253 | Human | 51213 | Details Get a Quote |
| LUZP4 Knockout A-549 Cell Line | EDJ-KQ64742 | Human | 51213 | Details Get a Quote |
| LUZP4 Knockout HCT 116 Cell Line | EDJ-KQ73187 | Human | 51213 | Details Get a Quote |
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