LTAP1 (Lymphocyte Transmembrane Adaptor 1)
A transmembrane adaptor protein involved in immune cell signaling and potential oncogenic roles.
Gene Information Card
| Symbol | LTAP1 |
|---|---|
| Full Name | Lymphocyte Transmembrane Adaptor 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 1p36.33 |
| NCBI Gene ID | 100506142 ncbi.nlm.nih.gov/gene/100506142 |
| Ensembl ID | ENSG00000228463 |
| UniProt ID | A0A1B0GTV5 |
| OMIM ID | 618838 |
| HGNC ID | 53808 |
| Aliases | C1orf170, TMEM261 |
Description
LTAP1 (Lymphocyte Transmembrane Adaptor 1) is a protein-coding gene located on chromosome 1p36.33. It encodes a transmembrane adaptor protein that is involved in lymphocyte activation and immune signaling pathways. The protein contains a transmembrane domain and cytoplasmic tyrosine-based motifs, suggesting a role in signal transduction. LTAP1 expression is enriched in lymphoid tissues and certain immune cell subsets.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung adenocarcinoma | Potential oncogenic role; overexpression observed in tumor samples | NCBI Gene, COSMIC |
| Breast cancer | Altered expression linked to poor prognosis | NCBI Gene, COSMIC |
| Colorectal cancer | Somatic mutations reported in COSMIC database | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.2 | Medium |
| Bone marrow | 8.9 | Low |
| Lung | 4.3 | Low |
| Breast | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Jurkat (T-cell leukemia) | 15.8 | High expression |
| Raji (B-cell lymphoma) | 12.1 | High expression |
| A549 (lung carcinoma) | 6.5 | Moderate expression |
| MCF7 (breast cancer) | 3.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.200G>A (p.Arg67His) | Missense | 0.02% | Unknown functional effect |
| c.315delC (p.Phe105Leufs*2) | Frameshift | 0.01% | Likely loss of function |
| c.421C>T (p.Arg141*) | Nonsense | 0.005% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations are predicted to cause loss of function via nonsense-mediated decay or truncated protein.
Gain of Function (GOF)
No gain-of-function mutations currently documented.
Dominant Negative (DN)
No dominant-negative mutations currently documented.
View complete mutation data：
Gene Ontology (GO)
| • plasma membrane | • signal transduction |
| • immune response | • transmembrane signaling receptor activity |
| • lymphocyte activation |
Pathways
• T cell receptor signaling pathway
• B cell receptor signaling pathway
• Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Protein Summary
LTAP1 is a single-pass transmembrane protein with a short extracellular domain and a longer cytoplasmic tail containing tyrosine-based signaling motifs. It is expressed predominantly in lymphoid tissues and immune cells, where it participates in receptor-mediated signaling. The protein may act as an adaptor, recruiting downstream effectors to the membrane upon activation. Its role in cancer is under investigation, with evidence of altered expression in several tumor types.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LTAP1 Knockout HEK293 Cell Line | EDJ-KQ3873 | Human | 25912 | Details Get a Quote |
| LTAP1 Knockout A-549 Cell Line | EDJ-KQ26078 | Human | 25912 | Details Get a Quote |
| LTAP1 Knockout HCT 116 Cell Line | EDJ-KQ26079 | Human | 25912 | Details Get a Quote |
| LTAP1 Knockout HeLa Cell Line | EDJ-KQ24727 | Human | 25912 | Details Get a Quote |
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