LSM14B
LSM Family Member 14B
Gene Information Card
| Symbol | LSM14B |
|---|---|
| Full Name | LSM Family Member 14B |
| Gene Type | protein-coding |
| Chromosomal Location | 20q13.33 |
| NCBI Gene ID | 149986 ncbi.nlm.nih.gov/gene/149986 |
| Ensembl ID | ENSG00000125868 |
| UniProt ID | Q9BX40 |
| OMIM ID | 614180 |
| HGNC ID | 29367 |
| Aliases | C20orf40, RAP55B, LSM14, LSM14B |
Description
LSM14B is a protein-coding gene that encodes a member of the LSM (Like Sm) family of RNA-binding proteins. The protein localizes to cytoplasmic processing bodies (P-bodies) and is involved in mRNA decapping, translational repression, and RNA metabolism. It plays a role in germ cell development and may be implicated in cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Altered expression may affect mRNA stability and translation in tumor cells | COSMIC |
| Male infertility | Involved in spermatogenesis via P-body function | OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Ovary | 8.5 | Low |
| Brain | 6.1 | Low |
| Lung | 4.3 | Low |
| Liver | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 12.0 | Moderate expression |
| HeLa | 9.5 | Moderate expression |
| K562 | 7.8 | Low expression |
| A549 | 6.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown effect |
| c.100C>T | missense | <0.01% | Unknown effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • RNA binding | • mRNA binding |
| • cytoplasmic mRNA processing body | • regulation of translation |
| • mRNA catabolic process |
Pathways
• mRNA surveillance pathway
• RNA degradation
Protein Summary
The LSM14B protein contains an LSM domain and a FDF domain, enabling it to bind RNA and localize to P-bodies. It interacts with DCP1/DCP2 decapping complex components and is essential for mRNA decapping and translational repression. It is highly expressed in testis and plays a role in spermatogenesis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LSM14B Knockout HEK293 Cell Line | EDJ-KQ11241 | Human | 149986 | Details Get a Quote |
| LSM14B Knockout A-549 Cell Line | EDJ-KQ39329 | Human | 149986 | Details Get a Quote |
| LSM14B Knockout HCT 116 Cell Line | EDJ-KQ39330 | Human | 149986 | Details Get a Quote |
| LSM14B Knockout HeLa Cell Line | EDJ-KQ39331 | Human | 149986 | Details Get a Quote |
