LSM14A Gene
LSM14A, a component of RNA processing bodies, involved in mRNA decapping and translational repression.
Gene Information Card
| Symbol | LSM14A |
|---|---|
| Full Name | LSM14A, mRNA processing body assembly factor |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.11 |
| NCBI Gene ID | 26065 ncbi.nlm.nih.gov/gene/26065 |
| Ensembl ID | ENSG00000105669 |
| UniProt ID | Q8ND56 |
| OMIM ID | 610577 |
| HGNC ID | 29372 |
| Aliases | RAP55, RAP55A, C19orf13, LSM14 |
Description
LSM14A encodes a member of the LSM (like Sm) family of RNA-binding proteins. The protein localizes to cytoplasmic processing bodies (P-bodies) and is involved in mRNA decapping, translational repression, and RNA turnover. It plays a role in the regulation of gene expression at the post-transcriptional level and is implicated in cellular stress responses, viral replication, and cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | LSM14A overexpression correlates with poor prognosis; may promote tumorigenesis via mRNA stability regulation | PMID: 25605274 |
| Hepatocellular carcinoma | Upregulated in HCC; associated with cell proliferation and migration | PMID: 27323850 |
| Neurodegenerative disorders | Potential role in stress granule dynamics; altered expression in Alzheimer's disease | PMID: 29100055 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 25.3 | High |
| Lymph node | 18.7 | Medium |
| Brain | 12.1 | Medium |
| Liver | 8.5 | Low |
| Heart | 6.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 22.4 | Cervical cancer cell line |
| HEK293 | 19.8 | Embryonic kidney cells |
| MCF7 | 15.6 | Breast cancer cell line |
| HepG2 | 14.3 | Hepatocellular carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.287A>G (p.Asn96Ser) | Missense | <0.01% | Unknown functional impact |
| c.512C>T (p.Pro171Leu) | Missense | <0.01% | Reported in ClinVar as uncertain significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in COSMIC or ClinVar.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • RNA binding | • mRNA binding |
| • P-body | • cytoplasmic stress granule |
| • regulation of mRNA stability | • negative regulation of translation |
| • mRNA catabolic process |
Pathways
• mRNA surveillance pathway
• RNA degradation
• Processing of capped intron-containing pre-mRNA
Protein Summary
LSM14A is a 446-amino acid protein containing an LSM domain and an FDF motif. It is a core component of P-bodies, where it interacts with decapping enzymes and RNA helicases to promote mRNA decay. The protein also shuttles between nucleus and cytoplasm and may participate in the assembly of stress granules under stress conditions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LSM14A Knockout HEK293 Cell Line | EDJ-KQ8382 | Human | 26065 | Details Get a Quote |
| LSM14A Knockout HeLa Cell Line | EDJ-KQ33100 | Human | 26065 | Details Get a Quote |
| LSM14A Knockout A-549 Cell Line | EDJ-KQ34434 | Human | 26065 | Details Get a Quote |
| LSM14A Knockout HCT 116 Cell Line | EDJ-KQ34435 | Human | 26065 | Details Get a Quote |
