LRRC36
Leucine-Rich Repeat Containing 36
Gene Information Card
| Symbol | LRRC36 |
|---|---|
| Full Name | Leucine-Rich Repeat Containing 36 |
| Gene Type | Protein-coding |
| Chromosomal Location | 16q24.1 |
| NCBI Gene ID | 146198 ncbi.nlm.nih.gov/gene/146198 |
| Ensembl ID | ENSG00000140937 |
| UniProt ID | Q5VWK5 |
| OMIM ID | 617169 |
| HGNC ID | 28346 |
| Aliases | FLJ32709, MGC16384 |
Description
LRRC36 encodes a protein containing leucine-rich repeats, which are typically involved in protein-protein interactions and signal transduction. The specific biological function of LRRC36 is not fully characterized, but it is predicted to play a role in cellular processes such as immune response or development.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease association reported | Not applicable | No evidence in ClinVar, OMIM, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Thyroid | 3.1 | Low |
| Adrenal gland | 2.8 | Low |
| Brain | 1.5 | Not detected |
| Heart | 0.9 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 4.0 | Low expression |
| K562 | 2.5 | Low expression |
| HeLa | 1.8 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • identical protein binding (GO:0042802) |
Pathways
• No curated pathways available
Protein Summary
The LRRC36 protein is 652 amino acids long and contains leucine-rich repeat domains. Its exact function is unknown, but it may participate in protein-protein interactions. Expression is low across most tissues, with highest levels in testis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LRRC36 Knockout HEK293 Cell Line | EDJ-KQ14127 | Human | 55282 | Details Get a Quote |
| LRRC36 Knockout HeLa Cell Line | EDJ-KQ56570 | Human | 55282 | Details Get a Quote |
| LRRC36 Knockout A-549 Cell Line | EDJ-KQ65067 | Human | 55282 | Details Get a Quote |
| LRRC36 Knockout HCT 116 Cell Line | EDJ-KQ73512 | Human | 55282 | Details Get a Quote |
