LPCAT4
Lysophosphatidylcholine Acyltransferase 4
Gene Information Card
| Symbol | LPCAT4 |
|---|---|
| Full Name | Lysophosphatidylcholine Acyltransferase 4 |
| Gene Type | Protein coding |
| Chromosomal Location | 15q14 |
| NCBI Gene ID | 254531 ncbi.nlm.nih.gov/gene/254531 |
| Ensembl ID | ENSG00000137869 |
| UniProt ID | Q6P1A2 |
| OMIM ID | 612829 |
| HGNC ID | 26017 |
| Aliases | LPEAT2, AYTL3, LPCAT-4, MBOAT2 |
Description
LPCAT4 (Lysophosphatidylcholine Acyltransferase 4) encodes an enzyme that catalyzes the conversion of lysophosphatidylcholine to phosphatidylcholine, a key step in phospholipid remodeling (Lands cycle). It is also known as LPEAT2 due to its activity on lysophosphatidylethanolamine. The protein is localized to the endoplasmic reticulum and is involved in membrane lipid homeostasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | Altered LPCAT4 expression may affect phospholipid composition and tumor growth | COSMIC, literature |
| Hepatocellular Carcinoma | Upregulation of LPCAT4 linked to lipid metabolism reprogramming | COSMIC, literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 8.3 | Low |
| Small Intestine | 6.1 | Low |
| Testis | 4.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 10.2 | Hepatocellular carcinoma cell line |
| Caco-2 | 7.8 | Colorectal adenocarcinoma cell line |
| HEK 293 | 5.4 | Embryonic kidney cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101G>A (p.Arg34His) | Missense | <0.01% | Unknown functional impact |
| c.452C>T (p.Thr151Met) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • 1-acylglycerol-3-phosphate O-acyltransferase activity | • lysophosphatidylcholine acyltransferase activity |
| • phospholipid biosynthetic process | • endoplasmic reticulum membrane |
Pathways
• Glycerophospholipid metabolism (Reactome: R-HSA-1483206)
• Lands cycle (Reactome: R-HSA-1482788)
Protein Summary
LPCAT4 is a 534-amino acid transmembrane protein belonging to the MBOAT (membrane-bound O-acyltransferase) family. It catalyzes the acylation of lysophospholipids, preferentially using arachidonoyl-CoA as an acyl donor. The enzyme plays a role in maintaining membrane lipid asymmetry and in the production of signaling lipids.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LPCAT4 Knockout HEK293 Cell Line | EDJ-KQ11772 | Human | 254531 | Details Get a Quote |
| LPCAT4 Knockout A-549 Cell Line | EDJ-KQ40172 | Human | 254531 | Details Get a Quote |
| LPCAT4 Knockout HCT 116 Cell Line | EDJ-KQ40173 | Human | 254531 | Details Get a Quote |
| LPCAT4 Knockout HeLa Cell Line | EDJ-KQ40174 | Human | 254531 | Details Get a Quote |
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