LPCAT3
Lysophosphatidylcholine Acyltransferase 3
Gene Information Card
| Symbol | LPCAT3 |
|---|---|
| Full Name | Lysophosphatidylcholine Acyltransferase 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 12p13.31 |
| NCBI Gene ID | 10162 ncbi.nlm.nih.gov/gene/10162 |
| Ensembl ID | ENSG00000111665 |
| UniProt ID | Q6P1A2 |
| OMIM ID | 611201 |
| HGNC ID | 26028 |
| Aliases | LPCAT3, AYTL2, LPLAT5, MBOAT5, OACT5, LPCAT-3 |
Description
LPCAT3 encodes lysophosphatidylcholine acyltransferase 3, a membrane-bound enzyme that catalyzes the conversion of lysophosphatidylcholine to phosphatidylcholine, playing a key role in phospholipid remodeling and membrane lipid composition. It is involved in lipid metabolism, cell signaling, and membrane fluidity regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | Altered LPCAT3 expression affects phospholipid composition and tumor growth | PMID: 25944712 |
| Non-alcoholic fatty liver disease (NAFLD) | LPCAT3 deficiency impairs hepatic lipid homeostasis | PMID: 29251726 |
| Atherosclerosis | LPCAT3 modulates macrophage foam cell formation and inflammation | PMID: 26216934 |
| Colorectal cancer | LPCAT3 upregulation linked to altered membrane lipid metabolism | PMID: 27323811 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 32.5 | High |
| Adipose tissue | 18.2 | Medium |
| Small intestine | 15.8 | Medium |
| Kidney | 12.1 | Medium |
| Lung | 8.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 45.3 | Hepatocellular carcinoma cell line |
| Caco-2 | 28.7 | Colorectal adenocarcinoma cell line |
| A549 | 12.6 | Lung carcinoma cell line |
| HEK293 | 9.8 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1045C>T (p.Arg349Trp) | Missense | 0.001% (gnomAD) | Unknown functional effect |
| c.788G>A (p.Arg263Gln) | Missense | 0.002% (gnomAD) | Unknown functional effect |
| c.1234delA (p.Thr412fs) | Frameshift | Rare | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., p.Thr412fs) are predicted to cause loss of enzyme activity.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • 1-acylglycerol-3-phosphate O-acyltransferase activity (GO:0003841) | • integral component of membrane (GO:0016021) |
| • lipid metabolic process (GO:0006629) | • phospholipid biosynthetic process (GO:0008654) |
| • phosphatidylcholine metabolic process (GO:0046470) |
Pathways
• REACT:1483257: Phospholipid metabolism
• REACT:111045: Glycerophospholipid biosynthesis
• KEGG:00564: Glycerophospholipid metabolism
Protein Summary
LPCAT3 is a 487-amino acid integral membrane protein belonging to the MBOAT family. It localizes to the endoplasmic reticulum and catalyzes the acylation of lysophosphatidylcholine to produce phosphatidylcholine, a major membrane phospholipid. The enzyme is critical for maintaining membrane lipid asymmetry and fluidity, and its dysregulation is implicated in metabolic and inflammatory diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LPCAT3 Knockout HEK293 Cell Line | EDJ-KQ2008 | Human | 10162 | Details Get a Quote |
| LPCAT3 Knockout A-549 Cell Line | EDJ-KQ22025 | Human | 10162 | Details Get a Quote |
| LPCAT3 Knockout HCT 116 Cell Line | EDJ-KQ22026 | Human | 10162 | Details Get a Quote |
| LPCAT3 Knockout HeLa Cell Line | EDJ-KQ22027 | Human | 10162 | Details Get a Quote |
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