LPAR6 (Lysophosphatidic Acid Receptor 6)
A G protein-coupled receptor for lysophosphatidic acid involved in hair growth and cancer
Gene Information Card
| Symbol | LPAR6 |
|---|---|
| Full Name | Lysophosphatidic Acid Receptor 6 |
| Gene Type | Protein coding |
| Chromosomal Location | 13q14.2 |
| NCBI Gene ID | 10161 ncbi.nlm.nih.gov/gene/10161 |
| Ensembl ID | ENSG00000139679 |
| UniProt ID | P43657 |
| OMIM ID | 609239 |
| HGNC ID | 15520 |
| Aliases | P2RY5, LPA6, P2Y5 |
Description
LPAR6 encodes a G protein-coupled receptor (GPCR) that binds lysophosphatidic acid (LPA) as its primary ligand. It is involved in cell proliferation, migration, and differentiation. Mutations in LPAR6 are associated with autosomal recessive hypotrichosis (hair loss). The receptor is also implicated in cancer progression and metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hypotrichosis 8 (HYPT8) | Loss-of-function mutations in LPAR6 impair LPA signaling in hair follicles, leading to abnormal hair growth and progressive hair loss. | OMIM #278150; ClinVar |
| Woolly hair (autosomal recessive) | Same LPAR6 mutations disrupt hair shaft formation, causing tightly curled, fragile hair. | OMIM #278150; ClinVar |
| Cancer (various) | LPAR6 overexpression or gain-of-function may promote tumor cell proliferation, migration, and invasion via LPA signaling. | COSMIC; PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Skin | 5.2 | Low |
| Adipose tissue | 3.8 | Low |
| Brain | 2.1 | Not detected |
| Heart | 1.5 | Not detected |
| Liver | 0.9 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HaCaT (keratinocytes) | 4.1 | High expression relevant to hair follicle |
| MCF7 (breast cancer) | 3.5 | Moderate expression |
| A549 (lung cancer) | 2.8 | Low expression |
| HEK293 | 1.2 | Low endogenous expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.346C>T (p.Arg116*) | Nonsense | Rare | Loss of function; associated with hypotrichosis |
| c.436G>A (p.Gly146Arg) | Missense | Rare | Loss of function; disrupts ligand binding |
| c.565C>T (p.Arg189Trp) | Missense | Rare | Loss of function; impaired signaling |
| c.736C>T (p.Arg246*) | Nonsense | Rare | Loss of function; truncated protein |
Mutation functional classification
Loss of Function (LOF)
Most LPAR6 mutations in hypotrichosis are loss-of-function, reducing or abolishing LPA-induced signaling.
Gain of Function (GOF)
Rare activating mutations reported in some cancers (e.g., COSMIC), leading to constitutive signaling.
Dominant Negative (DN)
Not documented for LPAR6.
View complete mutation data：
Gene Ontology (GO)
Pathways
• LPA signaling via GPCRs (Reactome: R-HSA-418594)
• GPCR downstream signaling (Reactome: R-HSA-388396)
• G alpha (i) signaling events (Reactome: R-HSA-418594)
Protein Summary
LPAR6 (LPA6) is a 344-amino acid G protein-coupled receptor with seven transmembrane domains. It is activated by lysophosphatidic acid (LPA), coupling primarily to Gαi/o proteins to inhibit adenylyl cyclase and activate MAPK and Rho pathways. The receptor is critical for hair follicle development and cycling. Loss-of-function mutations cause autosomal recessive hypotrichosis and woolly hair. In cancer, LPAR6 can promote tumor growth and metastasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LPAR6 Knockout HEK293 Cell Line | EDJ-KQ1722 | Human | 10161 | Details Get a Quote |
| LPAR6 Knockout A-549 Cell Line | EDJ-KQ21555 | Human | 10161 | Details Get a Quote |
| LPAR6 Knockout HeLa Cell Line | EDJ-KQ55331 | Human | 10161 | Details Get a Quote |
| LPAR6 Knockout HCT 116 Cell Line | EDJ-KQ72274 | Human | 10161 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
