LMTK2
Lemur Tyrosine Kinase 2: A Serine/Threonine Kinase Involved in Endocytosis and Cancer
Gene Information Card
| Symbol | LMTK2 |
|---|---|
| Full Name | Lemur tyrosine kinase 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 7q21.3 |
| NCBI Gene ID | 22853 ncbi.nlm.nih.gov/gene/22853 |
| Ensembl ID | ENSG00000106367 |
| UniProt ID | Q8IWU2 |
| OMIM ID | 610989 |
| HGNC ID | 17880 |
| Aliases | KPI-2, LMR2, cprk, PPP1R100, AATYK2 |
Description
LMTK2 (lemur tyrosine kinase 2) encodes a serine/threonine kinase that belongs to the lemur kinase family. The protein contains an N-terminal kinase domain, a transmembrane domain, and a long cytoplasmic tail. It is involved in endocytic trafficking, regulation of protein phosphatase 1 (PP1), and androgen receptor signaling. LMTK2 is implicated in prostate cancer, Alzheimer disease, and other neurological conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | LMTK2 modulates androgen receptor signaling and endocytosis; loss of function may promote tumor progression | OMIM 610989; ClinVar |
| Alzheimer disease | LMTK2 interacts with amyloid precursor protein (APP) and regulates APP trafficking and processing | UniProt Q8IWU2; NCBI Gene |
| Intellectual disability | Rare variants in LMTK2 have been associated with neurodevelopmental phenotypes | ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Prostate | 8.3 | Medium |
| Testis | 6.1 | Low |
| Lung | 4.7 | Low |
| Kidney | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PC-3 (prostate cancer) | 10.2 | Androgen-independent line |
| LNCaP (prostate cancer) | 7.8 | Androgen-sensitive line |
| SH-SY5Y (neuroblastoma) | 9.1 | Neuronal model |
| HEK293 (embryonic kidney) | 5.4 | Common expression model |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.2113C>T (p.Arg705Trp) | Missense | <0.01% | Reported in prostate cancer; functional impact unknown |
| c.2875C>T (p.Arg959Cys) | Missense | <0.01% | Associated with intellectual disability in ClinVar |
| c.1234del (p.Leu412Trpfs*5) | Frameshift deletion | Rare | Predicted loss-of-function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense variants that truncate the kinase domain or C-terminal region are predicted to cause loss of function.
Gain of Function (GOF)
No confirmed gain-of-function mutations have been reported in LMTK2.
Dominant Negative (DN)
No dominant-negative mechanisms have been described for LMTK2.
View complete mutation data：
Gene Ontology (GO)
| • protein serine/threonine kinase activity | • ATP binding |
| • protein binding | • endocytosis |
| • protein phosphorylation | • regulation of protein phosphatase type 1 activity |
| • membrane |
Pathways
• Endocytosis (Reactome R-HSA-199991)
• Signaling by Receptor Tyrosine Kinases (Reactome R-HSA-9006934)
• Androgen receptor signaling (Reactome R-HSA-5627123)
Protein Summary
LMTK2 is a 1509-amino-acid transmembrane serine/threonine kinase. It localizes to endosomes and the plasma membrane, where it regulates endocytic trafficking by phosphorylating components of the clathrin machinery. It also binds and inhibits protein phosphatase 1 (PP1), thereby modulating phosphorylation-dependent signaling. In neurons, LMTK2 influences APP processing and neurite outgrowth. In prostate cells, it interacts with androgen receptor and may act as a tumor suppressor.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LMTK2 Knockout HEK293 Cell Line | EDJ-KQ3648 | Human | 22853 | Details Get a Quote |
| LMTK2 Knockout A-549 Cell Line | EDJ-KQ25613 | Human | 22853 | Details Get a Quote |
| LMTK2 Knockout HCT 116 Cell Line | EDJ-KQ25614 | Human | 22853 | Details Get a Quote |
| LMTK2 Knockout HeLa Cell Line | EDJ-KQ25615 | Human | 22853 | Details Get a Quote |
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