LMO7: LIM Domain Only 7 - Gene and Protein Overview
Comprehensive biomedical resource for LMO7, including gene card, expression, mutations, and disease associations.
Gene Information Card
| Symbol | LMO7 |
|---|---|
| Full Name | LIM domain only 7 |
| Gene Type | protein-coding |
| Chromosomal Location | 13q22.2 |
| NCBI Gene ID | 4008 ncbi.nlm.nih.gov/gene/4008 |
| Ensembl ID | ENSG00000106633 |
| UniProt ID | Q8WWI1 |
| OMIM ID | 604362 |
| HGNC ID | 6648 |
| Aliases | FBX20, FBXO20, KIAA0858, LMO-7 |
Description
LMO7 (LIM domain only 7) is a protein-coding gene located on chromosome 13q22.2. It encodes a protein containing LIM domains and a calponin homology domain, involved in cell adhesion, cytoskeletal organization, and transcriptional regulation. LMO7 interacts with actin and transcription factors, playing roles in muscle development and cancer progression. Alternative splicing yields multiple transcript variants.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | LMO7 overexpression promotes cell migration and invasion via actin cytoskeleton remodeling | PMID: 23468909; COSMIC |
| Colorectal cancer | LMO7 downregulation associated with poor prognosis and EMT activation | PMID: 25636874; ClinVar |
| Emery-Dreifuss muscular dystrophy | LMO7 mutations disrupt nuclear envelope integrity and muscle cell adhesion | PMID: 17924336; OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 12.5 | Medium |
| Skeletal muscle | 10.3 | Medium |
| Breast | 6.8 | Low |
| Colon | 4.2 | Low |
| Lung | 3.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 15.2 | High expression |
| HCT116 (colorectal cancer) | 8.9 | Moderate expression |
| HEK293 (embryonic kidney) | 5.4 | Low expression |
| A549 (lung cancer) | 2.1 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <0.1% | Loss of function; truncation |
| c.567G>A (p.Glu189Lys) | Missense | 0.2% | Unknown; predicted damaging |
| c.890_891insA (p.Asn297Lysfs*5) | Frameshift | <0.1% | Loss of function; premature stop |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations in LMO7 lead to truncated protein lacking functional LIM domains, impairing actin binding and nuclear localization.
Gain of Function (GOF)
Not well characterized; some missense variants may enhance protein stability or interaction with transcription factors, but evidence is limited.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported; potential if mutant protein interferes with wild-type LMO7 in dimerization or scaffolding.
View complete mutation data：
Gene Ontology (GO)
| • actin binding | • protein kinase binding |
| • LIM domain binding | • cell adhesion |
| • cytoskeleton organization | • transcription coregulator activity |
| • nucleus | • cytoplasm |
| • cell junction |
Pathways
• Actin cytoskeleton regulation
• Focal adhesion
• TGF-beta signaling
• Nuclear envelope organization
Protein Summary
LMO7 is a 170 kDa protein containing N-terminal calponin homology domain and C-terminal LIM domains. It localizes to the cytoplasm, nucleus, and cell junctions. LMO7 binds actin filaments and interacts with transcription factors such as ERM and YAP, modulating gene expression. It is implicated in cell adhesion, migration, and muscle integrity. Post-translational modifications include phosphorylation and ubiquitination.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LMO7 Knockout HEK293 Cell Line | EDJ-KQ1134 | Human | 4008 | Details Get a Quote |
| LMO7 Knockout HeLa Cell Line | EDJ-KQ19002 | Human | 4008 | Details Get a Quote |
| LMO7 Knockout A-549 Cell Line | EDJ-KQ20346 | Human | 4008 | Details Get a Quote |
| LMO7 Knockout HCT 116 Cell Line | EDJ-KQ20347 | Human | 4008 | Details Get a Quote |
