LMO2 Gene
LIM Domain Only 2: A Key Regulator in Hematopoiesis and Oncogenesis
Gene Information Card
| Symbol | LMO2 |
|---|---|
| Full Name | LIM domain only 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 11p13 |
| NCBI Gene ID | 4005 ncbi.nlm.nih.gov/gene/4005 |
| Ensembl ID | ENSG00000135363 |
| UniProt ID | P25791 |
| OMIM ID | 180385 |
| HGNC ID | 6642 |
| Aliases | RBTN2, TTG2, RBTNL1 |
Description
LMO2 (LIM domain only 2) encodes a cysteine-rich LIM domain protein that functions as a transcriptional regulator. It is essential for hematopoiesis, particularly erythropoiesis and angiogenesis. LMO2 acts as a bridging molecule in transcription factor complexes, often interacting with GATA1, TAL1, and LDB1. Aberrant expression due to chromosomal translocations or retroviral insertions is strongly associated with T-cell acute lymphoblastic leukemia (T-ALL).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| T-cell acute lymphoblastic leukemia | Chromosomal translocations (e.g., t(11;14)(p13;q11)) cause LMO2 overexpression, disrupting T-cell differentiation. | ClinVar, OMIM, COSMIC |
| Angioimmunoblastic T-cell lymphoma | LMO2 overexpression via promoter hypomethylation or copy number gains. | COSMIC, NCBI |
| Hemoglobinopathies (indirect) | LMO2 is required for erythropoiesis; dysregulation may affect red blood cell development. | UniProt, NCBI |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone marrow | 12.5 | Medium |
| Spleen | 8.3 | Medium |
| Thymus | 6.7 | Low |
| Lymph node | 5.1 | Low |
| Brain | 1.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K562 (erythroleukemia) | 45.2 | High expression; used as model for erythropoiesis |
| Jurkat (T-cell leukemia) | 32.8 | High expression; relevant to T-ALL |
| HEK293 (embryonic kidney) | 2.1 | Low endogenous expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| t(11;14)(p13;q11) | Translocation | Common in T-ALL | LMO2 placed under TCR regulatory elements, causing overexpression |
| c.1A>G (p.Met1?) | Missense | Rare | Potential loss of start codon; effect uncertain |
| Amplification (11p13) | Copy number gain | ~5% in T-ALL | Increased LMO2 expression |
Mutation functional classification
Loss of Function (LOF)
Not commonly reported; LMO2 is essential for normal hematopoiesis, and loss-of-function is likely embryonic lethal.
Gain of Function (GOF)
Overexpression due to translocation or amplification drives T-ALL by blocking T-cell differentiation and promoting proliferation.
Dominant Negative (DN)
Not described for LMO2.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Hematopoietic stem cell differentiation (Reactome: R-HSA-9616222)
• Transcriptional regulation by LMO2/TAL1 complex (Reactome: R-HSA-9616225)
• T-cell receptor signaling in T-ALL (KEGG: hsa05260)
Protein Summary
LMO2 is a 156-amino acid protein containing two LIM zinc-binding domains. It lacks a DNA-binding domain and functions as a scaffold, bridging transcription factors such as GATA1, TAL1, and LDB1. This complex regulates genes critical for erythroid and T-cell development. In cancer, LMO2 overexpression disrupts normal differentiation, contributing to leukemogenesis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LMO2 Knockout HEK293 Cell Line | EDJ-KQ5130 | Human | 4005 | Details Get a Quote |
| ELMO2 Knockout HEK293 Cell Line | EDJ-KQ13274 | Human | 63916 | Details Get a Quote |
| LMO2 Knockout HCT 116 Cell Line | EDJ-KQ28092 | Human | 4005 | Details Get a Quote |
| ELMO2 Knockout A-549 Cell Line | EDJ-KQ42689 | Human | 63916 | Details Get a Quote |
| ELMO2 Knockout HCT 116 Cell Line | EDJ-KQ42690 | Human | 63916 | Details Get a Quote |
| ELMO2 Knockout HeLa Cell Line | EDJ-KQ42691 | Human | 63916 | Details Get a Quote |
| LMO2 Knockout HeLa Cell Line | EDJ-KQ53797 | Human | 4005 | Details Get a Quote |
| LMO2 Knockout A-549 Cell Line | EDJ-KQ62275 | Human | 4005 | Details Get a Quote |
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