LINC02210-CRHR1
Long intergenic non-protein coding RNA 2210 - Corticotropin Releasing Hormone Receptor 1 read-through transcript
Gene Information Card
| Symbol | LINC02210-CRHR1 |
|---|---|
| Full Name | LINC02210-CRHR1 read-through (NMD candidate) |
| Gene Type | Read-through transcript (non-coding, NMD candidate) |
| Chromosomal Location | 17q21.31 |
| NCBI Gene ID | 100874339 ncbi.nlm.nih.gov/gene/100874339 |
| Ensembl ID | ENSG00000267260 |
| UniProt ID | N/A (non-coding) |
| OMIM ID | N/A |
| HGNC ID | HGNC:40087 |
| Aliases | CRHR1-IT1, LINC02210-CRHR1 |
Description
LINC02210-CRHR1 is a read-through transcript that spans the genomic region between LINC02210 (a long intergenic non-protein coding RNA) and CRHR1 (corticotropin releasing hormone receptor 1). This transcript is classified as a nonsense-mediated decay (NMD) candidate and is not expected to produce a functional protein. The CRHR1 gene, which is part of this read-through locus, encodes a G protein-coupled receptor for corticotropin-releasing hormone (CRH), a key regulator of the hypothalamic-pituitary-adrenal (HPA) axis. CRHR1 mediates stress responses, anxiety, and mood regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Major Depressive Disorder | CRHR1 signaling dysregulation in HPA axis | Genetic association studies (PMID: 18470927) |
| Anxiety Disorders | Altered CRH-CRHR1 signaling in amygdala and prefrontal cortex | GWAS and candidate gene studies (PMID: 19037231) |
| Post-Traumatic Stress Disorder | CRHR1 polymorphisms linked to stress response variability | Meta-analysis (PMID: 23978897) |
| Cushing Disease | CRHR1 overexpression in pituitary corticotroph adenomas | Expression analysis (PMID: 15634725) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adrenal gland | 0.0 | Not detected |
| Brain - cortex | 0.0 | Not detected |
| Pituitary | 0.0 | Not detected |
| Heart | 0.0 | Not detected |
| Liver | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.0 | Not detected |
| HeLa | 0.0 | Not detected |
| K562 | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs110402 | SNP | Common (MAF ~0.4) | Intronic variant in CRHR1; associated with altered HPA axis reactivity |
| rs242924 | SNP | Common (MAF ~0.3) | Associated with depression and anxiety |
| rs878886 | SNP | Common (MAF ~0.2) | Linked to PTSD risk |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported for LINC02210-CRHR1 read-through transcript.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
Not applicable.
View complete mutation data：
Protein Summary
LINC02210-CRHR1 is a read-through transcript that does not encode a protein. The associated CRHR1 gene encodes a 415-amino acid G protein-coupled receptor (UniProt P34998) that binds corticotropin-releasing hormone and activates Gs-mediated cAMP signaling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LINC02210-CRHR1 Knockout HEK293 Cell Line | EDJ-KQ52527 | Human | 104909134 | Details Get a Quote |
| LINC02210-CRHR1 Knockout HeLa Cell Line | EDJ-KQ61008 | Human | 104909134 | Details Get a Quote |
| LINC02210-CRHR1 Knockout A-549 Cell Line | EDJ-KQ69482 | Human | 104909134 | Details Get a Quote |
| LINC02210-CRHR1 Knockout HCT 116 Cell Line | EDJ-KQ77835 | Human | 104909134 | Details Get a Quote |
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