LGR6 Gene: Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 6
A key regulator of stem cell function, Wnt signaling, and potential oncogene in cancer.
Gene Information Card
| Symbol | LGR6 |
|---|---|
| Full Name | Leucine-rich repeat-containing G protein-coupled receptor 6 |
| Gene Type | Protein coding |
| Chromosomal Location | 1q32.1 |
| NCBI Gene ID | 26471 ncbi.nlm.nih.gov/gene/26471 |
| Ensembl ID | ENSG00000133069 |
| UniProt ID | Q9HBX8 |
| OMIM ID | 606637 |
| HGNC ID | 19700 |
| Aliases | GPCR, GPR, LGR6.1, LGR6.2, LGR6.3 |
Description
LGR6 (leucine-rich repeat-containing G protein-coupled receptor 6) is a member of the LGR family of receptors that bind R-spondins and potentiate Wnt/β-catenin signaling. It is expressed in stem cell compartments and plays a role in tissue regeneration, hair follicle development, and cancer. LGR6 is considered a marker of multipotent stem cells in the skin and other epithelia.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | LGR6 overexpression or mutation may enhance Wnt signaling, promoting cell proliferation and tumorigenesis. | COSMIC, ClinVar |
| Hair follicle disorders | LGR6 is required for hair follicle stem cell maintenance; dysregulation may lead to alopecia or abnormal hair growth. | OMIM 606637 |
| Colorectal cancer | LGR6 is upregulated in colorectal cancer and associated with poor prognosis via Wnt pathway activation. | NCBI Gene, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Skin | 15.2 | Medium |
| Esophagus | 12.8 | Medium |
| Breast | 8.5 | Low |
| Colon | 7.3 | Low |
| Lung | 6.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HaCaT (keratinocyte) | 22.4 | High expression in skin-derived cells |
| MCF7 (breast cancer) | 9.8 | Moderate expression |
| HCT116 (colorectal cancer) | 14.1 | Elevated expression |
| A549 (lung cancer) | 5.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Cys) | Missense | 0.02% | Unknown functional effect; reported in COSMIC |
| c.567G>A (p.Trp189*) | Nonsense | 0.01% | Likely loss of function |
| c.2000_2001insA | Frameshift | 0.005% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations in LGR6 are predicted to truncate the protein, impairing R-spondin binding and Wnt signaling.
Gain of Function (GOF)
Missense mutations in the extracellular domain may enhance receptor activity, but evidence is limited.
Dominant Negative (DN)
No dominant-negative mutations have been reported for LGR6.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • Wnt signaling pathway |
| • cell surface receptor signaling pathway | • positive regulation of cell proliferation |
| • stem cell population maintenance |
Pathways
• Wnt/β-catenin signaling pathway
• R-spondin-mediated signaling
• GPCR signaling
Protein Summary
LGR6 is a 967-amino acid transmembrane protein with a large extracellular domain containing leucine-rich repeats. It functions as a receptor for R-spondins (RSPO1-4), which enhance Wnt/β-catenin signaling by stabilizing Frizzled receptors. LGR6 is highly expressed in stem cell niches and is implicated in tissue homeostasis and cancer.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LGR6 Knockout HEK293 Cell Line | EDJ-KQ14065 | Human | 59352 | Details Get a Quote |
| LGR6 Knockout HeLa Cell Line | EDJ-KQ43972 | Human | 59352 | Details Get a Quote |
| LGR6 Knockout A-549 Cell Line | EDJ-KQ65474 | Human | 59352 | Details Get a Quote |
| LGR6 Knockout HCT 116 Cell Line | EDJ-KQ73913 | Human | 59352 | Details Get a Quote |
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