LBP Gene - Lipopolysaccharide Binding Protein
Key mediator of innate immune response to bacterial lipopolysaccharide
Gene Information Card
| Symbol | LBP |
|---|---|
| Full Name | Lipopolysaccharide Binding Protein |
| Gene Type | protein-coding |
| Chromosomal Location | 20q11.23 |
| NCBI Gene ID | 3929 ncbi.nlm.nih.gov/gene/3929 |
| Ensembl ID | ENSG00000122122 |
| UniProt ID | P18428 |
| OMIM ID | 151990 |
| HGNC ID | 6517 |
| Aliases | BPI, BPIFD2 |
Description
LBP encodes lipopolysaccharide binding protein, a soluble acute-phase protein that binds to bacterial lipopolysaccharide (LPS) and facilitates its recognition by the CD14/TLR4 receptor complex, thereby initiating innate immune responses. LBP is primarily produced by hepatocytes and epithelial cells and plays a critical role in host defense against Gram-negative bacteria.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Sepsis | LBP binds LPS and enhances TLR4 signaling; elevated levels correlate with sepsis severity | PMID: 10415056 |
| Gram-negative bacterial infections | LBP facilitates LPS recognition and clearance; polymorphisms affect susceptibility | PMID: 11323673 |
| Inflammatory bowel disease | LBP levels elevated in Crohn's disease and ulcerative colitis; reflects mucosal inflammation | PMID: 17206706 |
| Atherosclerosis | LBP mediates LPS-induced inflammation in vascular endothelium; associated with cardiovascular risk | PMID: 15817888 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 68.5 | High |
| Lung | 12.3 | Medium |
| Small intestine | 9.8 | Medium |
| Kidney | 4.2 | Low |
| Heart | 1.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 45.2 | Hepatocyte cell line |
| A549 | 8.7 | Lung epithelial cell line |
| THP-1 | 3.5 | Monocyte cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.130C>T (p.Pro44Ser) | missense | <0.01% | Reduced LPS binding affinity |
| c.538G>A (p.Gly180Arg) | missense | <0.01% | Altered protein stability |
| c.913C>T (p.Arg305Trp) | missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants (e.g., p.Pro44Ser) reduce LPS binding and impair innate immune signaling.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in LBP.
Dominant Negative (DN)
No dominant-negative mutations described for LBP.
View complete mutation data：
Gene Ontology (GO)
| • lipopolysaccharide binding (GO:0001530) | • immune system process (GO:0002376) |
| • inflammatory response (GO:0006954) | • extracellular space (GO:0005615) |
| • innate immune response (GO:0045087) |
Pathways
• Toll-like receptor signaling pathway (KEGG: hsa04620)
• Lipopolysaccharide binding and CD14/TLR4 activation (Reactome: R-HSA-166016)
Protein Summary
Lipopolysaccharide binding protein (LBP) is a 58 kDa acute-phase glycoprotein secreted by the liver. It binds with high affinity to the lipid A moiety of bacterial LPS and transfers it to CD14, which then activates TLR4 signaling. LBP is essential for the host response to Gram-negative bacteria but can also contribute to excessive inflammation in sepsis and chronic inflammatory diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LBP Knockout HEK293 Cell Line | EDJ-KQ141 | Human | 3929 | Details Get a Quote |
| RALBP1 Knockout HEK293 Cell Line | EDJ-KQ1254 | Human | 10928 | Details Get a Quote |
| HDLBP Knockout HEK293 Cell Line | EDJ-KQ4860 | Human | 3069 | Details Get a Quote |
| RLBP1 Knockout HEK293 Cell Line | EDJ-KQ5673 | Human | 6017 | Details Get a Quote |
| ULBP1 Knockout HEK293 Cell Line | EDJ-KQ8767 | Human | 80329 | Details Get a Quote |
| ULBP2 Knockout HEK293 Cell Line | EDJ-KQ9521 | Human | 80328 | Details Get a Quote |
| ULBP3 Knockout HEK293 Cell Line | EDJ-KQ16026 | Human | 79465 | Details Get a Quote |
| ULBP3 Knockout A-549 Cell Line | EDJ-KQ47123 | Human | 79465 | Details Get a Quote |
| ULBP3 Knockout HCT 116 Cell Line | EDJ-KQ47124 | Human | 79465 | Details Get a Quote |
| ULBP3 Knockout HeLa Cell Line | EDJ-KQ47125 | Human | 79465 | Details Get a Quote |
| RALBP1 Knockout HeLa Cell Line | EDJ-KQ19277 | Human | 10928 | Details Get a Quote |
| RALBP1 Knockout A-549 Cell Line | EDJ-KQ20634 | Human | 10928 | Details Get a Quote |
| RALBP1 Knockout HCT 116 Cell Line | EDJ-KQ20635 | Human | 10928 | Details Get a Quote |
| HDLBP Knockout A-549 Cell Line | EDJ-KQ27637 | Human | 3069 | Details Get a Quote |
| HDLBP Knockout HCT 116 Cell Line | EDJ-KQ27638 | Human | 3069 | Details Get a Quote |
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